Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.

Bibliographic Details
Main Authors: Kyung Cheul Shin, Injae Hwang, Sung Sik Choe, Jeu Park, Yul Ji, Jong In Kim, Gha Young Lee, Sung Hee Choi, Jianhong Ching, Jean-Paul Kovalik, Jae Bum Kim
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01232-w

Internet

https://doi.org/10.1038/s41467-017-01232-w

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