Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production.
Granulomatosis with polyangiitis (GPA) is an autoimmune disease affecting mainly small blood vessels. B-cells are important in the GPA pathogenesis as precursors of autoantibody-producing cells but likely also contribute (auto)antibody-independently. This has been underlined by the effectiveness of...
Main Authors: | Anouk von Borstel, Wayel H Abdulahad, Gerjan Dekkema, Abraham Rutgers, Coen A Stegeman, Johanna Veldman, Peter Heeringa, Jan Stephan Sanders |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0235743 |
Similar Items
-
CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients
by: Anouk von Borstel, et al.
Published: (2019-09-01) -
Anti-enterovirus 71 activities of ribavirin, mycophenolic acid, and 6-azauridine
by: Zhao-Hong Li, et al.
Published: (2006) -
Modifications of total synthesis of mycophenolic acid
by: Grzegorz Cholewinski, et al.
Published: (2018-02-01) -
Studies on mycophenolic acid and lignan chemistry
by: Knittel, Peter
Published: (2011) -
Anti-Vasculogenic Effect of Mycophenolic Acid
by: Go, Ellen Lao
Published: (2019)