MiR-22 Inhibition Alleviates Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy by Targeting the sirt1/PGC-1α Pathway
Doxorubicin (DOX) cardiotoxicity is a life-threatening side effect that leads to a poor prognosis in patients receiving chemotherapy. We investigated the role of miR-22 in doxorubicin-induced cardiomyopathy and the underlying mechanism in vivo and in vitro. Specifically, we designed loss-of-function...
Main Authors: | Runze Wang, Yuerong Xu, Xiaolin Niu, Yexian Fang, Dong Guo, Jiangwei Chen, Hanzhao Zhu, Jiaying Dong, Ran Zhao, Ying Wang, Bingchao Qi, Gaotong Ren, Xue Li, Li Liu, Mingming Zhang |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.646903/full |
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