The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health
A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut m...
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doaj-67d56f0c73724adba4a930df578428052020-11-25T02:26:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-04-011010.3389/fmicb.2019.00709446326The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic HealthZhencheng Li0Torben Sølbeck Rasmussen1Mette Line Rasmussen2Jingwen Li3Carlos Henríquez Olguín4Witold Kot5Dennis Sandris Nielsen6Thomas Elbenhardt Jensen7Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkMicrobiology and Fermentation, Department of Food Science, University of Copenhagen, Frederiksberg, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkDepartment of Environmental Sciences, Aarhus University, Roskilde, DenmarkMicrobiology and Fermentation, Department of Food Science, University of Copenhagen, Frederiksberg, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkA periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut microbiome (GM) responds to both diet and exercise and may influence host metabolism. This study compared the cecal GM after a 13.5-week intervention study in mice on a variety of dietary interventions ± concurrent voluntary exercise training in activity wheels. The diets included chronic chow diet, LPHC diet, 40 E% high protein-low carbohydrate (HPLC) diet, an obesigenic chronic high-fat diet (HFD) and the pLPHC diet. Our hypothesis was that the GM changes with pLPHC diet would generally reflect the improved metabolic health of the host and interact with concurrent exercise training. The GM analyses revealed greater abundance phylum Bacteroidetes and the genus Akkermansia on chronic and periodized LPHC and higher abundance of Oscillospira and Oscillibacter on HFD. The differences in diet-induced GM correlated strongly with the differences in a range of host metabolic health-measures. In contrast, no significant effect of concurrent exercise training was observed. In conclusion, pLPHC diet elicits substantial changes in the GM. In contrast, only subtle and non-significant effects of concurrent activity wheel exercise were observed. The pLPHC-associated microbiome may contribute to the healthier host phenotype observed in these mice.https://www.frontiersin.org/article/10.3389/fmicb.2019.00709/fullmicrobiomeexerciselow protein dietperiodizedintermittent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhencheng Li Torben Sølbeck Rasmussen Mette Line Rasmussen Jingwen Li Carlos Henríquez Olguín Witold Kot Dennis Sandris Nielsen Thomas Elbenhardt Jensen |
spellingShingle |
Zhencheng Li Torben Sølbeck Rasmussen Mette Line Rasmussen Jingwen Li Carlos Henríquez Olguín Witold Kot Dennis Sandris Nielsen Thomas Elbenhardt Jensen The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health Frontiers in Microbiology microbiome exercise low protein diet periodized intermittent |
author_facet |
Zhencheng Li Torben Sølbeck Rasmussen Mette Line Rasmussen Jingwen Li Carlos Henríquez Olguín Witold Kot Dennis Sandris Nielsen Thomas Elbenhardt Jensen |
author_sort |
Zhencheng Li |
title |
The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health |
title_short |
The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health |
title_full |
The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health |
title_fullStr |
The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health |
title_full_unstemmed |
The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health |
title_sort |
gut microbiome on a periodized low-protein diet is associated with improved metabolic health |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2019-04-01 |
description |
A periodized (14 days on/14 days off) 5% low protein-high carbohydrate (pLPHC) diet protects against weight gain, improves glucose tolerance in mice and interacts with concurrent voluntary activity wheel training on several parameters including weight maintenance and liver FGF21 secretion. The gut microbiome (GM) responds to both diet and exercise and may influence host metabolism. This study compared the cecal GM after a 13.5-week intervention study in mice on a variety of dietary interventions ± concurrent voluntary exercise training in activity wheels. The diets included chronic chow diet, LPHC diet, 40 E% high protein-low carbohydrate (HPLC) diet, an obesigenic chronic high-fat diet (HFD) and the pLPHC diet. Our hypothesis was that the GM changes with pLPHC diet would generally reflect the improved metabolic health of the host and interact with concurrent exercise training. The GM analyses revealed greater abundance phylum Bacteroidetes and the genus Akkermansia on chronic and periodized LPHC and higher abundance of Oscillospira and Oscillibacter on HFD. The differences in diet-induced GM correlated strongly with the differences in a range of host metabolic health-measures. In contrast, no significant effect of concurrent exercise training was observed. In conclusion, pLPHC diet elicits substantial changes in the GM. In contrast, only subtle and non-significant effects of concurrent activity wheel exercise were observed. The pLPHC-associated microbiome may contribute to the healthier host phenotype observed in these mice. |
topic |
microbiome exercise low protein diet periodized intermittent |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2019.00709/full |
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