Elevated expression of G3BP1 associates with YB1 and p‐AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection

Elevated expression of G3BP1 associates with YB1 and p‐AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection

Abstract Purpose G3BP1 is an RNA‐binding protein and plays roles in regulating signaling pathway. YB‐1 is a DNA/RNA binding protein encoded by YBX1 gene. Phosphorylated AKT (p‐AKT) acts as a pivotal molecule in PI3K/AKT pathway. YB‐1 drives stress granules (SGs) formation by activating G3BP1 transla...

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Bibliographic Details
Main Authors: Hongmei Zheng, Yuting Zhan, Yuting Zhang, Sile Liu, Junmi Lu, Yang yang, Qiuyuan Wen, Songqing Fan
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Cancer Medicine
Subjects:
biomarker
G3BP1
nonsmall cell lung cancer
p‐AKT
prognosis
YB1
Online Access:https://doi.org/10.1002/cam4.2579

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