Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Abstract Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid...
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doaj-67eb35fa778b4432b4ea0b06f0dfedbe2020-11-25T01:29:36ZengWileyAdvanced Science2198-38442019-08-01616n/an/a10.1002/advs.201801664Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?Sepehr Talebian0Mehdi Mehrali1Nayere Taebnia2Cristian Pablo Pennisi3Firoz Babu Kadumudi4Javad Foroughi5Masoud Hasany6Mehdi Nikkhah7Mohsen Akbari8Gorka Orive9Alireza Dolatshahi‐Pirouz10Intelligent Polymer Research Institute ARC Centre of Excellence for Electromaterials Science AIIM Facility University of Wollongong NSW 2522 AustraliaDTU Nanotech Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark Lyngby 2800 Kgs DenmarkDTU Nanotech Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark Lyngby 2800 Kgs DenmarkLaboratory for Stem Cell Research Department of Health Science and Technology Aalborg University Fredrik Bajers vej 3B 9220 Aalborg DenmarkDTU Nanotech Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark Lyngby 2800 Kgs DenmarkIntelligent Polymer Research Institute ARC Centre of Excellence for Electromaterials Science AIIM Facility University of Wollongong NSW 2522 AustraliaDTU Nanotech Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark Lyngby 2800 Kgs DenmarkSchool of Biological Health and Systems Engineering (SBHSE) Arizona State University Tempe AZ 85287 USALaboratory for Innovations in MicroEngineering (LiME) Department of Mechanical Engineering University of Victoria Victoria BC V8P 5C2 CanadaNanoBioCel Group Laboratory of Pharmaceutics School of Pharmacy University of the Basque Country UPV/EHU Paseo de la Universidad 7 01006 Vitoria‐Gasteiz SpainDTU Nanotech Center for Intestinal Absorption and Transport of Biopharmaceuticals Technical University of Denmark Lyngby 2800 Kgs DenmarkAbstract Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self‐healing remains unaddressed, and therefore most of the self‐healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self‐healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double‐network hydrogels is showing great promise as a feasible way to generate self‐healable hydrogels with the above‐mentioned attributes. Here, the recent progress in the development of multifunctional and self‐healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.https://doi.org/10.1002/advs.201801664cyborganicsnanocomposite hydrogelsnanomaterialsself‐healing hydrogelstissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sepehr Talebian Mehdi Mehrali Nayere Taebnia Cristian Pablo Pennisi Firoz Babu Kadumudi Javad Foroughi Masoud Hasany Mehdi Nikkhah Mohsen Akbari Gorka Orive Alireza Dolatshahi‐Pirouz |
spellingShingle |
Sepehr Talebian Mehdi Mehrali Nayere Taebnia Cristian Pablo Pennisi Firoz Babu Kadumudi Javad Foroughi Masoud Hasany Mehdi Nikkhah Mohsen Akbari Gorka Orive Alireza Dolatshahi‐Pirouz Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? Advanced Science cyborganics nanocomposite hydrogels nanomaterials self‐healing hydrogels tissue engineering |
author_facet |
Sepehr Talebian Mehdi Mehrali Nayere Taebnia Cristian Pablo Pennisi Firoz Babu Kadumudi Javad Foroughi Masoud Hasany Mehdi Nikkhah Mohsen Akbari Gorka Orive Alireza Dolatshahi‐Pirouz |
author_sort |
Sepehr Talebian |
title |
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? |
title_short |
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? |
title_full |
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? |
title_fullStr |
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? |
title_full_unstemmed |
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? |
title_sort |
self‐healing hydrogels: the next paradigm shift in tissue engineering? |
publisher |
Wiley |
series |
Advanced Science |
issn |
2198-3844 |
publishDate |
2019-08-01 |
description |
Abstract Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self‐healing remains unaddressed, and therefore most of the self‐healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self‐healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double‐network hydrogels is showing great promise as a feasible way to generate self‐healable hydrogels with the above‐mentioned attributes. Here, the recent progress in the development of multifunctional and self‐healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted. |
topic |
cyborganics nanocomposite hydrogels nanomaterials self‐healing hydrogels tissue engineering |
url |
https://doi.org/10.1002/advs.201801664 |
work_keys_str_mv |
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