Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status

Abstract Objectives The development of non‐sputum‐based assays for tuberculosis (TB) diagnosis and treatment monitoring is a key priority. Recent data indicate that whole blood‐based assays to assess the phenotype of Mycobacterium tuberculosis (Mtb)‐specific CD4 T cells hold promise for this purpose...

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Bibliographic Details
Main Authors: Catherine Riou, Elsa Du Bruyn, Sheena Ruzive, Rene T Goliath, Cecilia S Lindestam Arlehamn, Alessandro Sette, Alan Sher, Daniel L Barber, Robert J Wilkinson
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
tuberculosis
CD4 response
disease severity
treatment response
Online Access:https://doi.org/10.1002/cti2.1176

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