Curcumin plays a synergistic role in combination with HSV-TK/GCV in inhibiting growth of murine B16 melanoma cells and melanoma xenografts
Melanoma is a global concern and accounts for the major mortality of skin cancers. Herpes simplex virus thymidine kinase gene with ganciclovir (HSV-TK/GCV) is a promising gene therapy for melanoma. Despite its low efficiency, it is well known for its bystander effect which is mainly mediated by gap...
Main Authors: | Hong Li, Haiyan Du, Guangxian Zhang, Yingya Wu, Pengxiang Qiu, Jingjing Liu, Jing Guo, Xijuan Liu, Lingling Sun, Biaoyan Du, Yuhui Tan |
---|---|
Format: | Article |
Language: | English |
Published: |
PeerJ Inc.
2019-09-01
|
Series: | PeerJ |
Subjects: | |
Online Access: | https://peerj.com/articles/7760.pdf |
Similar Items
-
Estudios de factores que condicionan la sensibilidad del tratamiento con TK/GCV. Diseño de estrategias combinadas para potenciar la citotoxicidad de TK/GCV: Silenciamiento de genes antiapópticos y virus oncolíticos armados con TK
by: Abate-Daga, Daniel
Published: (2009) -
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
by: Lei-qing Li, et al.
Published: (2013-01-01) -
Regulation of the yifK locus by multi-target small RNA GcvB in Salmonella
by: Yang, Qi
Published: (2013) -
Antitumor Efficacy of Oncolytic Herpes Virus Type 1 Armed with GM-CSF in Murine Uveal Melanoma Xenografts
by: Liu S, et al.
Published: (2020-11-01) -
HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer
by: Midan Ai, et al.
Published: (2008-09-01)