The Influence of Adipokines on Fetal Bone Turnover
"nBackground: A relation between adiponectin and bone homeostasis has been illustrated through studying adiponectin se­cretion and its receptor presentation in bone forming cells. The aim of our study was to investigate the relationship between fetal bone turnover and adipokines...
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Tehran University of Medical Sciences
2008-11-01
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doaj-6815d3df3e0f47eb8f918eefcded76372020-12-02T00:35:19ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852008-11-0137sup3640The Influence of Adipokines on Fetal Bone TurnoverA Moradi ZirkohiZh MaghbooliA Hossein-nezhadF ZareF BandarianH SaghafiB Larijani"nBackground: A relation between adiponectin and bone homeostasis has been illustrated through studying adiponectin se­cretion and its receptor presentation in bone forming cells. The aim of our study was to investigate the relationship between fetal bone turnover and adipokines."nMethods: In a cross-sectional study performed in Tehran University of medical sciences related hospitals, 77 samples (39 males, 38 females) of umbilical cord blood immediately after delivery were gathered. Clinical characteristics such as gen­der, weight, length, weight to length ratio were recorded. Measurements of leptin, adiponectin, osteocalcin and crosslaps were done by ELISA methods in biochemistry and hormone laboratory of endocrinology and metabolism research center. The amounts of crosslaps and osteocalcin were expressed as t-scores, and then t-scores of crosslaps was subtracted from osteocalcin t-scores to establish estimation for bone formation, which we named Bone Formation Index."nResults: In Univariate Analysis, after entrance sex, birth weight and birth length as fixed factors, leptin and adiponectin displayed an independent effect on Bone Formation Index."nConclusion: Our data suggest that both leptin and adiponectin have a remarkable impact on bone turnover in fetus.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/12888.pdf&manuscript_id=12888LeptinAdiponectinOsteocalcinCrosslapsUmbilical cordBone Turnover |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A Moradi Zirkohi Zh Maghbooli A Hossein-nezhad F Zare F Bandarian H Saghafi B Larijani |
spellingShingle |
A Moradi Zirkohi Zh Maghbooli A Hossein-nezhad F Zare F Bandarian H Saghafi B Larijani The Influence of Adipokines on Fetal Bone Turnover Iranian Journal of Public Health Leptin Adiponectin Osteocalcin Crosslaps Umbilical cord Bone Turnover |
author_facet |
A Moradi Zirkohi Zh Maghbooli A Hossein-nezhad F Zare F Bandarian H Saghafi B Larijani |
author_sort |
A Moradi Zirkohi |
title |
The Influence of Adipokines on Fetal Bone Turnover |
title_short |
The Influence of Adipokines on Fetal Bone Turnover |
title_full |
The Influence of Adipokines on Fetal Bone Turnover |
title_fullStr |
The Influence of Adipokines on Fetal Bone Turnover |
title_full_unstemmed |
The Influence of Adipokines on Fetal Bone Turnover |
title_sort |
influence of adipokines on fetal bone turnover |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 |
publishDate |
2008-11-01 |
description |
"nBackground: A relation between adiponectin and bone homeostasis has been illustrated through studying adiponectin se­cretion and its receptor presentation in bone forming cells. The aim of our study was to investigate the relationship between fetal bone turnover and adipokines."nMethods: In a cross-sectional study performed in Tehran University of medical sciences related hospitals, 77 samples (39 males, 38 females) of umbilical cord blood immediately after delivery were gathered. Clinical characteristics such as gen­der, weight, length, weight to length ratio were recorded. Measurements of leptin, adiponectin, osteocalcin and crosslaps were done by ELISA methods in biochemistry and hormone laboratory of endocrinology and metabolism research center. The amounts of crosslaps and osteocalcin were expressed as t-scores, and then t-scores of crosslaps was subtracted from osteocalcin t-scores to establish estimation for bone formation, which we named Bone Formation Index."nResults: In Univariate Analysis, after entrance sex, birth weight and birth length as fixed factors, leptin and adiponectin displayed an independent effect on Bone Formation Index."nConclusion: Our data suggest that both leptin and adiponectin have a remarkable impact on bone turnover in fetus. |
topic |
Leptin Adiponectin Osteocalcin Crosslaps Umbilical cord Bone Turnover |
url |
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/12888.pdf&manuscript_id=12888 |
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