Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion

Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion

Abstract Background Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting in failure of ADSC-based therapy. Methods In this study, ADSCs were treat...

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Bibliographic Details
Main Authors: Naishun Liao, Yingjun Shi, Cuilin Zhang, Youshi Zheng, Yingchao Wang, Bixing Zhao, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Stem Cell Research & Therapy
Subjects:
Adipose tissue-derived mesenchymal stem cells
Reduced glutathione
Melatonin
ROS
Senescence
Stemness
Online Access:http://link.springer.com/article/10.1186/s13287-019-1404-9

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