Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer
Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association...
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Frontiers Media S.A.
2019-08-01
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Series: | Frontiers in Genetics |
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Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.00730/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elena A. Pudova Elena N. Lukyanova Kirill M. Nyushko Dmitry S. Mikhaylenko Dmitry S. Mikhaylenko Andrew R. Zaretsky Anastasiya V. Snezhkina Maria V. Savvateeva Anastasiya A. Kobelyatskaya Nataliya V. Melnikova Nadezhda N. Volchenko Gennady D. Efremov Kseniya M. Klimina Anastasiya A. Belova Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev George S. Krasnov Anna V. Kudryavtseva |
spellingShingle |
Elena A. Pudova Elena N. Lukyanova Kirill M. Nyushko Dmitry S. Mikhaylenko Dmitry S. Mikhaylenko Andrew R. Zaretsky Anastasiya V. Snezhkina Maria V. Savvateeva Anastasiya A. Kobelyatskaya Nataliya V. Melnikova Nadezhda N. Volchenko Gennady D. Efremov Kseniya M. Klimina Anastasiya A. Belova Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev George S. Krasnov Anna V. Kudryavtseva Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer Frontiers in Genetics locally advanced prostate cancer prognostic markers TCGA RNA-Seq TMPRSS2-ERG |
author_facet |
Elena A. Pudova Elena N. Lukyanova Kirill M. Nyushko Dmitry S. Mikhaylenko Dmitry S. Mikhaylenko Andrew R. Zaretsky Anastasiya V. Snezhkina Maria V. Savvateeva Anastasiya A. Kobelyatskaya Nataliya V. Melnikova Nadezhda N. Volchenko Gennady D. Efremov Kseniya M. Klimina Anastasiya A. Belova Marina V. Kiseleva Andrey D. Kaprin Boris Y. Alekseev George S. Krasnov Anna V. Kudryavtseva |
author_sort |
Elena A. Pudova |
title |
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_short |
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_full |
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_fullStr |
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_full_unstemmed |
Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer |
title_sort |
differentially expressed genes associated with prognosis in locally advanced lymph node-negative prostate cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2019-08-01 |
description |
Older age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between older age and disease onset. Carcinogenesis is followed by the deregulation of many genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We have performed a bioinformatic analysis of a The Cancer Genome Atlas (TCGA) data and RNA-Seq profiling of a Russian patient cohort to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph node-negative LAPC). We also aimed to identify markers of the most common molecular subtype of prostate cancer carrying a fusion transcript TMPRSS2-ERG. We have found several genes that were differently expressed between the favorable and unfavorable prognosis groups and involved in the enriched KEGG pathways based on the TCGA (B4GALNT4, PTK6, and CHAT) and Russian patient cohort data (AKR1C1 and AKR1C3). Additionally, we revealed such genes for the TMPRSS2-ERG prostate cancer molecular subtype (B4GALNT4, ASRGL1, MYBPC1, RGS11, SLC6A14, GALNT13, and ST6GALNAC1). Obtained results contribute to a better understanding of the molecular mechanisms behind prostate cancer progression and could be used for further development of the LAPC prognosis marker panel. |
topic |
locally advanced prostate cancer prognostic markers TCGA RNA-Seq TMPRSS2-ERG |
url |
https://www.frontiersin.org/article/10.3389/fgene.2019.00730/full |
work_keys_str_mv |
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doaj-681d84d579e044259747d8b4d86688bf2020-11-25T02:46:37ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-08-011010.3389/fgene.2019.00730417807Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate CancerElena A. Pudova0Elena N. Lukyanova1Kirill M. Nyushko2Dmitry S. Mikhaylenko3Dmitry S. Mikhaylenko4Andrew R. Zaretsky5Anastasiya V. Snezhkina6Maria V. Savvateeva7Anastasiya A. Kobelyatskaya8Nataliya V. Melnikova9Nadezhda N. Volchenko10Gennady D. Efremov11Kseniya M. Klimina12Anastasiya A. Belova13Marina V. Kiseleva14Andrey D. Kaprin15Boris Y. Alekseev16George S. Krasnov17Anna V. Kudryavtseva18Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaFederal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaNational Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, RussiaOlder age is one of the main risk factors for cancer development. The incidence of prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate cancer most frequently occurs in men over 60 years of age, indicating a clear association between older age and disease onset. Carcinogenesis is followed by the deregulation of many genes, and some of these changes could serve as biomarkers for diagnosis, prognosis, prediction of drug therapy efficacy, as well as possible therapeutic targets. We have performed a bioinformatic analysis of a The Cancer Genome Atlas (TCGA) data and RNA-Seq profiling of a Russian patient cohort to reveal prognostic markers of locally advanced lymph node-negative prostate cancer (lymph node-negative LAPC). We also aimed to identify markers of the most common molecular subtype of prostate cancer carrying a fusion transcript TMPRSS2-ERG. We have found several genes that were differently expressed between the favorable and unfavorable prognosis groups and involved in the enriched KEGG pathways based on the TCGA (B4GALNT4, PTK6, and CHAT) and Russian patient cohort data (AKR1C1 and AKR1C3). Additionally, we revealed such genes for the TMPRSS2-ERG prostate cancer molecular subtype (B4GALNT4, ASRGL1, MYBPC1, RGS11, SLC6A14, GALNT13, and ST6GALNAC1). Obtained results contribute to a better understanding of the molecular mechanisms behind prostate cancer progression and could be used for further development of the LAPC prognosis marker panel.https://www.frontiersin.org/article/10.3389/fgene.2019.00730/fulllocally advanced prostate cancerprognostic markersTCGARNA-SeqTMPRSS2-ERG |