Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior

Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior

Summary: Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABAA subunit-containing GABAA receptors (δGABAARs) that respond to ambient GABA levels and context-dependent neuromodulators like steroids. We find that GC-specific deletion of δGABAA (cerebellar [cb] δ knockout [KO]...

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Bibliographic Details
Main Authors: Stephanie Rudolph, Chong Guo, Stan L. Pashkovski, Tomas Osorno, Winthrop F. Gillis, Jeremy M. Krauss, Hajnalka Nyitrai, Isabella Flaquer, Mahmoud El-Rifai, Sandeep Robert Datta, Wade G. Regehr
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
cerebellum
tonic inhibition
GABAA
hyperexcitability
anxiety-like behavior
social behavior
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313279

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