Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice
We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days...
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doaj-68231d0c6063444ab1db22bfbea604542020-11-24T22:01:17ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-011054367371Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in MiceEun-Joo Shin0Ji Hoon Jeong1Hyun Ji Kim2Choon-Gon Jang3Kiyofumi Yamada4Toshitaka Nabeshima5Hyoung-Chun Kim6Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaDepartment of Pharmacology, College of Medicine, Chung Ang University, Seoul, KoreaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaDepartment of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon 400-746, KoreaDepartment of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanDepartment of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan; Department of Chemical Pharmacology, Meijo University Graduate School of Pharmaceutical Sciences, Nagoya 468-8503, JapanNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea; Corresponding author. kimhc@kangwon.ac.krWe demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF–induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF–induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors. Keywords:: extremely low frequency magnetic field, locomotor activity, dopaminergic receptorhttp://www.sciencedirect.com/science/article/pii/S1347861319341830 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eun-Joo Shin Ji Hoon Jeong Hyun Ji Kim Choon-Gon Jang Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim |
spellingShingle |
Eun-Joo Shin Ji Hoon Jeong Hyun Ji Kim Choon-Gon Jang Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice Journal of Pharmacological Sciences |
author_facet |
Eun-Joo Shin Ji Hoon Jeong Hyun Ji Kim Choon-Gon Jang Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim |
author_sort |
Eun-Joo Shin |
title |
Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice |
title_short |
Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice |
title_full |
Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice |
title_fullStr |
Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice |
title_full_unstemmed |
Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice |
title_sort |
exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine d1-like receptors in mice |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2007-01-01 |
description |
We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF–induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF–induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors. Keywords:: extremely low frequency magnetic field, locomotor activity, dopaminergic receptor |
url |
http://www.sciencedirect.com/science/article/pii/S1347861319341830 |
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