Mutation in the Ciliary Protein C2CD3 Reveals Organ-Specific Mechanisms of Hedgehog Signal Transduction in Avian Embryos

Mutation in the Ciliary Protein C2CD3 Reveals Organ-Specific Mechanisms of Hedgehog Signal Transduction in Avian Embryos

Primary cilia are ubiquitous microtubule-based organelles that serve as signaling hubs for numerous developmental pathways, most notably the Hedgehog (Hh) pathway. Defects in the structure or function of primary cilia result in a class of diseases called ciliopathies. It is well known that primary c...

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Bibliographic Details
Main Authors: Evan C. Brooks, Christian Louis Bonatto Paese, Anne H. Carroll, Jaime N. Struve, Nandor Nagy, Samantha A. Brugmann
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Developmental Biology
Subjects:
primary cilia
ciliopathies
Hedgehog signaling
<i>talpid</i><sup>2</sup>
C2CD3
hindgut
Online Access:https://www.mdpi.com/2221-3759/9/2/12

Internet

https://www.mdpi.com/2221-3759/9/2/12

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