Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to lower postprandial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis. This effect is mediated by the Glut4 glucose transporter. Growth factors also enhance glucose uptak...

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Bibliographic Details
Main Authors: Muheeb Beg, Nazish Abdullah, Fathima Shazna Thowfeik, Nasser K Altorki, Timothy E McGraw
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
Akt
mTORC2
Glut4
Glut1
insulin action
Online Access:https://elifesciences.org/articles/26896

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