Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits.
Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association s...
Main Authors: | Guanghao Qi, Nilanjan Chatterjee |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-10-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC6192650?pdf=render |
Similar Items
-
Hipo Histérico
by: Luis G. Bustamante O.
Published: (1938-09-01) -
Enrichment of Heritability Across Several Hypertension Related Traits
by: Zhang, Xueyi, Zhang
Published: (2018) -
Discromias (hipo e hiperpigmentações) em idade pediátrica
by: Inês Barros Rua
Published: (2019) -
Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits
by: Abdellaoui, A., et al.
Published: (2021) -
Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
by: Guanghao Qi, et al.
Published: (2019-04-01)