Circadian Host-Microbiome Interactions in Immunity
The gut microbiome plays a critical role in regulating host immunity and can no longer be regarded as a bystander in human health and disease. In recent years, circadian (24 h) oscillations have been identified in the composition of the microbiota, its biophysical localization within the intestinal...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01783/full |
id |
doaj-68355b45a04b407594e977e953c7e22a |
---|---|
record_format |
Article |
spelling |
doaj-68355b45a04b407594e977e953c7e22a2020-11-25T04:01:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01783548650Circadian Host-Microbiome Interactions in ImmunityThomas D. ButlerJulie E. GibbsThe gut microbiome plays a critical role in regulating host immunity and can no longer be regarded as a bystander in human health and disease. In recent years, circadian (24 h) oscillations have been identified in the composition of the microbiota, its biophysical localization within the intestinal tract and its metabolic outputs. The gut microbiome and its key metabolic outputs, such as short chain fatty acids and tryptophan metabolites contribute to maintenance of intestinal immunity by promoting barrier function, regulating the host mucosal immune system and maintaining the function of gut-associated immune cell populations. Loss of rhythmic host-microbiome interactions disrupts host immunity and increases risk of inflammation and metabolic complications. Here we review factors that drive circadian variation in the microbiome, including meal timing, dietary composition and host circadian clocks. We also consider how host-microbiome interactions impact the core molecular clock and its rhythmic outputs in addition to the potential impact of this relationship on circadian control of immunity.https://www.frontiersin.org/article/10.3389/fimmu.2020.01783/fullmicrobiomecircadianimmunitydiurnalshort chain fatty acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas D. Butler Julie E. Gibbs |
spellingShingle |
Thomas D. Butler Julie E. Gibbs Circadian Host-Microbiome Interactions in Immunity Frontiers in Immunology microbiome circadian immunity diurnal short chain fatty acids |
author_facet |
Thomas D. Butler Julie E. Gibbs |
author_sort |
Thomas D. Butler |
title |
Circadian Host-Microbiome Interactions in Immunity |
title_short |
Circadian Host-Microbiome Interactions in Immunity |
title_full |
Circadian Host-Microbiome Interactions in Immunity |
title_fullStr |
Circadian Host-Microbiome Interactions in Immunity |
title_full_unstemmed |
Circadian Host-Microbiome Interactions in Immunity |
title_sort |
circadian host-microbiome interactions in immunity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-08-01 |
description |
The gut microbiome plays a critical role in regulating host immunity and can no longer be regarded as a bystander in human health and disease. In recent years, circadian (24 h) oscillations have been identified in the composition of the microbiota, its biophysical localization within the intestinal tract and its metabolic outputs. The gut microbiome and its key metabolic outputs, such as short chain fatty acids and tryptophan metabolites contribute to maintenance of intestinal immunity by promoting barrier function, regulating the host mucosal immune system and maintaining the function of gut-associated immune cell populations. Loss of rhythmic host-microbiome interactions disrupts host immunity and increases risk of inflammation and metabolic complications. Here we review factors that drive circadian variation in the microbiome, including meal timing, dietary composition and host circadian clocks. We also consider how host-microbiome interactions impact the core molecular clock and its rhythmic outputs in addition to the potential impact of this relationship on circadian control of immunity. |
topic |
microbiome circadian immunity diurnal short chain fatty acids |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01783/full |
work_keys_str_mv |
AT thomasdbutler circadianhostmicrobiomeinteractionsinimmunity AT julieegibbs circadianhostmicrobiomeinteractionsinimmunity |
_version_ |
1724446540597035008 |