Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.

Bibliographic Details
Main Authors:	Gang Zhang, Blanca Lopez Mendez, Garry G. Sedgwick, Jakob Nilsson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12256

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spelling	doaj-683703f88b40405d9999b5a8529ec7612021-05-11T10:50:26ZengNature Publishing GroupNature Communications2041-17232016-07-017111210.1038/ncomms12256Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregationGang Zhang0Blanca Lopez Mendez1Garry G. Sedgwick2Jakob Nilsson3The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical SciencesThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical SciencesThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical SciencesThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical SciencesThe BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.https://doi.org/10.1038/ncomms12256
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson
spellingShingle	Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation Nature Communications
author_facet	Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson
author_sort	Gang Zhang
title	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_short	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_full	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_fullStr	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_full_unstemmed	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_sort	two functionally distinct kinetochore pools of bubr1 ensure accurate chromosome segregation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-07-01
description	The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.
url	https://doi.org/10.1038/ncomms12256
work_keys_str_mv	AT gangzhang twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT blancalopezmendez twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT garrygsedgwick twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT jakobnilsson twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation
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Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

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