Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients
We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8+ Melan-A-specific T-cell functionality, enlarges the Melan-A+ TCR repertoire and impacts the overall survival of melanoma patients. To identify whether...
Main Authors: | Belinda Palermo, Ornella Franzese, Cosmo Di Donna, Mariangela Panetta, Concetta Quintarelli, Isabella Sperduti, Novella Gualtieri, Maria Laura Foddai, Enrico Proietti, Virginia Ferraresi, Gennaro Ciliberto, Paola Nisticò |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2018-12-01
|
Series: | OncoImmunology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/2162402X.2018.1465163 |
Similar Items
-
DNA vaccination amplifiers HLA-DR cross-restricted public TCR clonotypes shared with HIV controllers
by: Mukhopadhyay, Madhura
Published: (2017) -
Narrowing the gap: preserving repertoire diversity despite clonal selection during the CD4 T cell response
by: Julia eMerkenschlager, et al.
Published: (2015-08-01) -
TCR Analyses of Two Vast and Shared Melanoma Antigen-Specific T Cell Repertoires: Common and Specific Features
by: Sylvain Simon, et al.
Published: (2018-08-01) -
Coreceptors and TCR Signaling – the Strong and the Weak of It
by: Alexander M. Mørch, et al.
Published: (2020-10-01) -
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
by: Ilenia Aversa, et al.
Published: (2020-03-01)