Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation

Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation

HPV16 is the major viral human carcinogen responsible for between 3 and 4% of all cancers worldwide. Following infection, this virus activates the DNA damage response (DDR) to promote its life cycle and recruits DDR proteins to its replicating DNA in order to facilitate homologous recombination duri...

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Bibliographic Details
Main Authors: Dipon Das, Molly L. Bristol, Nathan W. Smith, Claire D. James, Xu Wang, Pietro Pichierri, Iain M. Morgan
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
DNA repair
DNA replication
E1-E2
SIRT1
WRN
cervical cancer
head and neck cancer
human papillomavirus
life cycle
Online Access:https://doi.org/10.1128/mBio.00263-19

Internet

https://doi.org/10.1128/mBio.00263-19

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