A-site mRNA cleavage is not required for tmRNA-mediated ssrA-peptide tagging.
In Escherichia coli, prolonged translational arrest allows mRNA degradation into the A site of stalled ribosomes. The enzyme that cleaves the A-site codon is not known, but its activity requires RNase II to degrade mRNA downstream of the ribosome. This A-site mRNA cleavage process is thought to func...
Main Authors: | Brian D Janssen, Fernando Garza-Sánchez, Christopher S Hayes |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3834316?pdf=render |
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