From Exercise to Cognitive Performance: Role of Irisin

• Main Authors: Mirko Pesce, Irene La Fratta, Teresa Paolucci, Alfredo Grilli, Antonia Patruno, Francesco Agostini, Andrea Bernetti, Massimiliano Mangone, Marco Paoloni, Marco Invernizzi, Alessandro de Sire
• Format: Article
• Language: English
• Published: MDPI AG 2021-07-01
• Series: Applied Sciences
• Subjects: irisin; FNDC5; PGC-1α; BDNF; physical exercise; brain
• Online Access: https://www.mdpi.com/2076-3417/11/15/7120

The beneficial effects of exercise on the brain are well known. In general, exercise offers an effective way to improve cognitive function in all ages, particularly in the elderly, who are considered the most vulnerable to neurodegenerative disorders. In this regard, myokines, hormones secreted by muscle in response to exercise, have recently gained attention as beneficial mediators. Irisin is a novel exercise-induced myokine, that modulates several bodily processes, such as glucose homeostasis, and reduces systemic inflammation. Irisin is cleaved from fibronectin type III domain containing 5 (FNDC5), a transmembrane precursor protein expressed in muscle under the control of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). The FNDC5/irisin system is also expressed in the hippocampus, where it stimulates the expression of the neurotrophin brain-derived neurotrophic factor in this area that is associated with learning and memory. In this review, we aimed to discuss the role of irisin as a key mediator of the beneficial effects of exercise on synaptic plasticity and memory in the elderly, suggesting its roles within the main promoters of the beneficial effects of exercise on the brain.