The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche
Notch and Wnt signaling are highly conserved intercellular communication pathways involved in developmental processes, such as hematopoiesis. Even though data from literature support a role for these two pathways in both physiological hematopoiesis and leukemia, there are still many controversies co...
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doaj-685d27067b77411784885f8bf0a3efd82021-01-08T05:11:20ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.599276599276The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow NichePaul Takam Kamga0Paul Takam Kamga1Riccardo Bazzoni2Giada Dal Collo3Adriana Cassaro4Adriana Cassaro5Ilaria Tanasi6Anna Russignan7Cristina Tecchio8Mauro Krampera9Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyEA4340-BCOH, Biomarker in Cancerology and Onco-Haematology, UVSQ, Université Paris Saclay, Boulogne-Billancourt, FranceStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyDepartment of Immunology, Erasmus University Medical Center, Rotterdam, NetherlandsHematology Unit, Department of Oncology, Niguarda Hospital, Milan, ItalyDepartment of Health Sciences, University of Milan, Milan, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyNotch and Wnt signaling are highly conserved intercellular communication pathways involved in developmental processes, such as hematopoiesis. Even though data from literature support a role for these two pathways in both physiological hematopoiesis and leukemia, there are still many controversies concerning the nature of their contribution. Early studies, strengthened by findings from T-cell acute lymphoblastic leukemia (T-ALL), have focused their investigation on the mutations in genes encoding for components of the pathways, with limited results except for B-cell chronic lymphocytic leukemia (CLL); in because in other leukemia the two pathways could be hyper-expressed without genetic abnormalities. As normal and malignant hematopoiesis require close and complex interactions between hematopoietic cells and specialized bone marrow (BM) niche cells, recent studies have focused on the role of Notch and Wnt signaling in the context of normal crosstalk between hematopoietic/leukemia cells and stromal components. Amongst the latter, mesenchymal stromal/stem cells (MSCs) play a pivotal role as multipotent non-hematopoietic cells capable of giving rise to most of the BM niche stromal cells, including fibroblasts, adipocytes, and osteocytes. Indeed, MSCs express and secrete a broad pattern of bioactive molecules, including Notch and Wnt molecules, that support all the phases of the hematopoiesis, including self-renewal, proliferation and differentiation. Herein, we provide an overview on recent advances on the contribution of MSC-derived Notch and Wnt signaling to hematopoiesis and leukemia development.https://www.frontiersin.org/articles/10.3389/fcell.2020.599276/fullMesenchymal stromal cellsNotchWntleukemiabone marrow niche |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paul Takam Kamga Paul Takam Kamga Riccardo Bazzoni Giada Dal Collo Adriana Cassaro Adriana Cassaro Ilaria Tanasi Anna Russignan Cristina Tecchio Mauro Krampera |
spellingShingle |
Paul Takam Kamga Paul Takam Kamga Riccardo Bazzoni Giada Dal Collo Adriana Cassaro Adriana Cassaro Ilaria Tanasi Anna Russignan Cristina Tecchio Mauro Krampera The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche Frontiers in Cell and Developmental Biology Mesenchymal stromal cells Notch Wnt leukemia bone marrow niche |
author_facet |
Paul Takam Kamga Paul Takam Kamga Riccardo Bazzoni Giada Dal Collo Adriana Cassaro Adriana Cassaro Ilaria Tanasi Anna Russignan Cristina Tecchio Mauro Krampera |
author_sort |
Paul Takam Kamga |
title |
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche |
title_short |
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche |
title_full |
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche |
title_fullStr |
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche |
title_full_unstemmed |
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche |
title_sort |
role of notch and wnt signaling in msc communication in normal and leukemic bone marrow niche |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-01-01 |
description |
Notch and Wnt signaling are highly conserved intercellular communication pathways involved in developmental processes, such as hematopoiesis. Even though data from literature support a role for these two pathways in both physiological hematopoiesis and leukemia, there are still many controversies concerning the nature of their contribution. Early studies, strengthened by findings from T-cell acute lymphoblastic leukemia (T-ALL), have focused their investigation on the mutations in genes encoding for components of the pathways, with limited results except for B-cell chronic lymphocytic leukemia (CLL); in because in other leukemia the two pathways could be hyper-expressed without genetic abnormalities. As normal and malignant hematopoiesis require close and complex interactions between hematopoietic cells and specialized bone marrow (BM) niche cells, recent studies have focused on the role of Notch and Wnt signaling in the context of normal crosstalk between hematopoietic/leukemia cells and stromal components. Amongst the latter, mesenchymal stromal/stem cells (MSCs) play a pivotal role as multipotent non-hematopoietic cells capable of giving rise to most of the BM niche stromal cells, including fibroblasts, adipocytes, and osteocytes. Indeed, MSCs express and secrete a broad pattern of bioactive molecules, including Notch and Wnt molecules, that support all the phases of the hematopoiesis, including self-renewal, proliferation and differentiation. Herein, we provide an overview on recent advances on the contribution of MSC-derived Notch and Wnt signaling to hematopoiesis and leukemia development. |
topic |
Mesenchymal stromal cells Notch Wnt leukemia bone marrow niche |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2020.599276/full |
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