Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

BACKGROUND: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments, therefore new effective targeted therapeutics must be identified. Increasing evidence shows epigenetic alterations including histone posttranslationa...

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Bibliographic Details
Main Authors: Rebecca Lewis, Yuping D Li, Lindsey Hoffman, Rintaro Hashizume, Gordan Gravohac, Gavin Rice, Nitin R Wadhwani, Chunfa Jie, Tatiana Pundy, Barbara Mania-Farnell, Chandra S Mayanil, Marcelo B Soares, Ting Lei, Charles D James, Nicolas K Foreman, Tadanori Tomita, Guifa Xi
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619300752

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