BEX1 is an RNA-dependent mediator of cardiomyopathy

Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory gene...

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Main Authors:	Federica Accornero, Tobias G. Schips, Jennifer M. Petrosino, Shan-Qing Gu, Onur Kanisicak, Jop H. van Berlo, Jeffery D. Molkentin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02005-1

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record_format	Article
spelling	doaj-6869b96703654f77bdb47ffe9c5e96362021-05-11T07:53:16ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-02005-1BEX1 is an RNA-dependent mediator of cardiomyopathyFederica Accornero0Tobias G. Schips1Jennifer M. Petrosino2Shan-Qing Gu3Onur Kanisicak4Jop H. van Berlo5Jeffery D. Molkentin6Cincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterDorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State UniversityDorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State UniversityCincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterLittle is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes.https://doi.org/10.1038/s41467-017-02005-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin
spellingShingle	Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin BEX1 is an RNA-dependent mediator of cardiomyopathy Nature Communications
author_facet	Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin
author_sort	Federica Accornero
title	BEX1 is an RNA-dependent mediator of cardiomyopathy
title_short	BEX1 is an RNA-dependent mediator of cardiomyopathy
title_full	BEX1 is an RNA-dependent mediator of cardiomyopathy
title_fullStr	BEX1 is an RNA-dependent mediator of cardiomyopathy
title_full_unstemmed	BEX1 is an RNA-dependent mediator of cardiomyopathy
title_sort	bex1 is an rna-dependent mediator of cardiomyopathy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes.
url	https://doi.org/10.1038/s41467-017-02005-1
work_keys_str_mv	AT federicaaccornero bex1isanrnadependentmediatorofcardiomyopathy AT tobiasgschips bex1isanrnadependentmediatorofcardiomyopathy AT jennifermpetrosino bex1isanrnadependentmediatorofcardiomyopathy AT shanqinggu bex1isanrnadependentmediatorofcardiomyopathy AT onurkanisicak bex1isanrnadependentmediatorofcardiomyopathy AT jophvanberlo bex1isanrnadependentmediatorofcardiomyopathy AT jefferydmolkentin bex1isanrnadependentmediatorofcardiomyopathy
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BEX1 is an RNA-dependent mediator of cardiomyopathy

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