BEX1 is an RNA-dependent mediator of cardiomyopathy
Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory gene...
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Nature Publishing Group
2017-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02005-1 |
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doaj-6869b96703654f77bdb47ffe9c5e96362021-05-11T07:53:16ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-02005-1BEX1 is an RNA-dependent mediator of cardiomyopathyFederica Accornero0Tobias G. Schips1Jennifer M. Petrosino2Shan-Qing Gu3Onur Kanisicak4Jop H. van Berlo5Jeffery D. Molkentin6Cincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterDorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State UniversityDorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State UniversityCincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterCincinnati Children’s Hospital Medical CenterLittle is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes.https://doi.org/10.1038/s41467-017-02005-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin |
spellingShingle |
Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin BEX1 is an RNA-dependent mediator of cardiomyopathy Nature Communications |
author_facet |
Federica Accornero Tobias G. Schips Jennifer M. Petrosino Shan-Qing Gu Onur Kanisicak Jop H. van Berlo Jeffery D. Molkentin |
author_sort |
Federica Accornero |
title |
BEX1 is an RNA-dependent mediator of cardiomyopathy |
title_short |
BEX1 is an RNA-dependent mediator of cardiomyopathy |
title_full |
BEX1 is an RNA-dependent mediator of cardiomyopathy |
title_fullStr |
BEX1 is an RNA-dependent mediator of cardiomyopathy |
title_full_unstemmed |
BEX1 is an RNA-dependent mediator of cardiomyopathy |
title_sort |
bex1 is an rna-dependent mediator of cardiomyopathy |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-11-01 |
description |
Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes. |
url |
https://doi.org/10.1038/s41467-017-02005-1 |
work_keys_str_mv |
AT federicaaccornero bex1isanrnadependentmediatorofcardiomyopathy AT tobiasgschips bex1isanrnadependentmediatorofcardiomyopathy AT jennifermpetrosino bex1isanrnadependentmediatorofcardiomyopathy AT shanqinggu bex1isanrnadependentmediatorofcardiomyopathy AT onurkanisicak bex1isanrnadependentmediatorofcardiomyopathy AT jophvanberlo bex1isanrnadependentmediatorofcardiomyopathy AT jefferydmolkentin bex1isanrnadependentmediatorofcardiomyopathy |
_version_ |
1721451400080130048 |