Constituintes químicos do caule de Spathelia excelsa (rutaceae) e atividade frente a Aedes aegypti Chemical constituents of the stems of Spathelia excelsa (rutaceae) and activity against Aedes aegypti

Constituintes químicos do caule de Spathelia excelsa (rutaceae) e atividade frente a Aedes aegypti Chemical constituents of the stems of Spathelia excelsa (rutaceae) and activity against Aedes aegypti

<abstract language="eng">Phytochemical investigation from the stems of Spathelia excelsa (Rutaceae) collected in Amazonas yielded deacetylspathelin (1), 7,8-dimethoxyflindersine (2), new glabretal-type triterpenoid 3&#946;-angeloyl-21,24-epoxy-7&#945;, 21&#945;, 23&#9...

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Bibliographic Details
Main Authors: Aline Carvalho de Freitas, Maria da Paz Lima, Antonio Gilberto Ferreira, Wanderli Pedro Tadei, Ana Cristina da Silva Pinto
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2009-01-01
Series:Química Nova
Subjects:
Spathelia excelsa
Aedes aegypti
adulticidal and larvicidal activities
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000800016
Description
Summary:<abstract language="eng">Phytochemical investigation from the stems of Spathelia excelsa (Rutaceae) collected in Amazonas yielded deacetylspathelin (1), 7,8-dimethoxyflindersine (2), new glabretal-type triterpenoid 3&#946;-angeloyl-21,24-epoxy-7&#945;, 21&#945;, 23&#945;, 25-tetrahydroxy-4&#945;, 4&#946;, 8&#946;, 10&#946;-tetramethyl-25-dimethyl-14, 18-cyclo-5&#945;, 13&#945;, 14&#945;, 17&#945;-cholestane (3), in addition to the known steroids &#946;-sitosterol and stigmasterol. Their structures were established on the basis of spectral data. The compounds 1 and 3 were assayed on Aedes aegypti (larvicidal and adulticidal activities and compound 3 exhibited larvicidal properties with LC50 of 4,8 µg/mL.
ISSN:0100-4042
1678-7064

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