Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators
Soshiho-tang (SST) is a well-known traditional herbal medicine used for the treatment of many diseases. The aims of this study are to investigate the effects of SST on atopic dermatitis (AD) symptoms and to examine its mechanism. Human keratinocyte (HaCaT) cells were stimulated with tumor necrosis f...
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doaj-687c09af584f447583512969ecb311432020-11-25T01:18:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-07-011010.3389/fphar.2019.00742444668Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory MediatorsJi-Hyun Lee0Eun Hee Jo1Eun Hee Jo2Bori Lee3Hyeon Min Noh4Sunggu Park5Young-Mi Lee6Dae-Ki Kim7Min Chel Park8Min Chel Park9Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, South KoreaResearch Center of Traditional Korean Medicine, Wonkwang University, Iksan, South KoreaDepartment of Acupuncture and Moxibustion, College of Korean Medicine, Wonkwang University, Iksan, South KoreaDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, South KoreaKorean Traditional Medicine Institute, Wonkwang University, Iksan, South KoreaDepartment of Korean Medical Ophthalmology & Otolarynglogy & Dermatology, College of Korean Medicine, Wonkwang University, Iksan, South KoreaDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, South KoreaDepartment of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, South KoreaResearch Center of Traditional Korean Medicine, Wonkwang University, Iksan, South KoreaDepartment of Korean Medical Ophthalmology & Otolarynglogy & Dermatology, College of Korean Medicine, Wonkwang University, Iksan, South KoreaSoshiho-tang (SST) is a well-known traditional herbal medicine used for the treatment of many diseases. The aims of this study are to investigate the effects of SST on atopic dermatitis (AD) symptoms and to examine its mechanism. Human keratinocyte (HaCaT) cells were stimulated with tumor necrosis factor alpha (TNF-α)/IFN-γ to induce AD-like keratinocyte environment. 2,4-Dinitrochlorobenzene (DNCB) was used to induce AD-like skin lesions in the dorsal skin of BALB/c mice. SST and dexamethasone were administered orally for 14 day. As a result, SST treatment increased the expression of heme oxygenase-1 (HO-1), an anti-oxidative factor, and the nuclear translocation of NF-E2 p45-related factor 2 (Nrf2). In addition, the treatment also decreased the expression level of inflammatory mediator nuclear factor-κB (NF-κB) and the adhesion molecule intercellular adhesion molecule-1 (ICAM-1). SST treatment (75 and 150 mg/kg) significantly relieved AD symptoms in DNCB-induced AD-like mice by restoring skin thickness, spleen weight, immunoglobulin E (IgE), interleukin 4 (IL-4), pro-inflammatory cytokine expression, and expression of several other mediators. We found that SST alleviates AD-like skin lesions and skin inflammation by modulating various atopic symptoms and inflammatory mediators. Therefore, SST can be used as an alternative drug for the treatment of AD.https://www.frontiersin.org/article/10.3389/fphar.2019.00742/fullSoshiho-Tangatopic dermatitis2,4-dinitrochlorobenzenekeratinocytesinflammationoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji-Hyun Lee Eun Hee Jo Eun Hee Jo Bori Lee Hyeon Min Noh Sunggu Park Young-Mi Lee Dae-Ki Kim Min Chel Park Min Chel Park |
spellingShingle |
Ji-Hyun Lee Eun Hee Jo Eun Hee Jo Bori Lee Hyeon Min Noh Sunggu Park Young-Mi Lee Dae-Ki Kim Min Chel Park Min Chel Park Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators Frontiers in Pharmacology Soshiho-Tang atopic dermatitis 2,4-dinitrochlorobenzene keratinocytes inflammation oxidative stress |
author_facet |
Ji-Hyun Lee Eun Hee Jo Eun Hee Jo Bori Lee Hyeon Min Noh Sunggu Park Young-Mi Lee Dae-Ki Kim Min Chel Park Min Chel Park |
author_sort |
Ji-Hyun Lee |
title |
Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators |
title_short |
Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators |
title_full |
Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators |
title_fullStr |
Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators |
title_full_unstemmed |
Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators |
title_sort |
soshiho-tang, a traditional herbal medicine, alleviates atopic dermatitis symptoms via regulation of inflammatory mediators |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2019-07-01 |
description |
Soshiho-tang (SST) is a well-known traditional herbal medicine used for the treatment of many diseases. The aims of this study are to investigate the effects of SST on atopic dermatitis (AD) symptoms and to examine its mechanism. Human keratinocyte (HaCaT) cells were stimulated with tumor necrosis factor alpha (TNF-α)/IFN-γ to induce AD-like keratinocyte environment. 2,4-Dinitrochlorobenzene (DNCB) was used to induce AD-like skin lesions in the dorsal skin of BALB/c mice. SST and dexamethasone were administered orally for 14 day. As a result, SST treatment increased the expression of heme oxygenase-1 (HO-1), an anti-oxidative factor, and the nuclear translocation of NF-E2 p45-related factor 2 (Nrf2). In addition, the treatment also decreased the expression level of inflammatory mediator nuclear factor-κB (NF-κB) and the adhesion molecule intercellular adhesion molecule-1 (ICAM-1). SST treatment (75 and 150 mg/kg) significantly relieved AD symptoms in DNCB-induced AD-like mice by restoring skin thickness, spleen weight, immunoglobulin E (IgE), interleukin 4 (IL-4), pro-inflammatory cytokine expression, and expression of several other mediators. We found that SST alleviates AD-like skin lesions and skin inflammation by modulating various atopic symptoms and inflammatory mediators. Therefore, SST can be used as an alternative drug for the treatment of AD. |
topic |
Soshiho-Tang atopic dermatitis 2,4-dinitrochlorobenzene keratinocytes inflammation oxidative stress |
url |
https://www.frontiersin.org/article/10.3389/fphar.2019.00742/full |
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