Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon
Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Y...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-08-01
|
Series: | Lipids in Health and Disease |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12944-017-0543-1 |
id |
doaj-68878a29d05a4665833bdc34ef6cb93a |
---|---|
record_format |
Article |
spelling |
doaj-68878a29d05a4665833bdc34ef6cb93a2020-11-24T21:35:04ZengBMCLipids in Health and Disease1476-511X2017-08-011611710.1186/s12944-017-0543-1Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from CameroonSteve Raoul Ngongang Noumegni0Jobert Richie Nansseu1Vicky Jocelyne Moor Ama2Jean Joel Bigna3Felix Kembe Assah4Magellan Guewo-Fokeng5Steve Leumi6Jean-Claude Katte7Mesmin Dehayem8Andre Pascal Kengne9Eugene Sobngwi10Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Faculty of Medicine, University of Paris Sud XIDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Department of Biochemistry, Faculty of Sciences, University of Yaoundé IDepartment of Biochemistry, Faculty of Sciences, University of Yaoundé INational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNon-Communicable Diseases Research Unit, South African Medical Research CouncilLaboratory of Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. Results We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10–4.72). Conclusion Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.http://link.springer.com/article/10.1186/s12944-017-0543-1Insulin resistanceHOMA-IRHIVCameroon |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Steve Raoul Ngongang Noumegni Jobert Richie Nansseu Vicky Jocelyne Moor Ama Jean Joel Bigna Felix Kembe Assah Magellan Guewo-Fokeng Steve Leumi Jean-Claude Katte Mesmin Dehayem Andre Pascal Kengne Eugene Sobngwi |
spellingShingle |
Steve Raoul Ngongang Noumegni Jobert Richie Nansseu Vicky Jocelyne Moor Ama Jean Joel Bigna Felix Kembe Assah Magellan Guewo-Fokeng Steve Leumi Jean-Claude Katte Mesmin Dehayem Andre Pascal Kengne Eugene Sobngwi Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon Lipids in Health and Disease Insulin resistance HOMA-IR HIV Cameroon |
author_facet |
Steve Raoul Ngongang Noumegni Jobert Richie Nansseu Vicky Jocelyne Moor Ama Jean Joel Bigna Felix Kembe Assah Magellan Guewo-Fokeng Steve Leumi Jean-Claude Katte Mesmin Dehayem Andre Pascal Kengne Eugene Sobngwi |
author_sort |
Steve Raoul Ngongang Noumegni |
title |
Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon |
title_short |
Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon |
title_full |
Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon |
title_fullStr |
Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon |
title_full_unstemmed |
Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon |
title_sort |
insulin resistance and associated factors among hiv-infected patients in sub-saharan africa: a cross sectional study from cameroon |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2017-08-01 |
description |
Abstract Background Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. Methods We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. Results We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10–4.72). Conclusion Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity. |
topic |
Insulin resistance HOMA-IR HIV Cameroon |
url |
http://link.springer.com/article/10.1186/s12944-017-0543-1 |
work_keys_str_mv |
AT steveraoulngongangnoumegni insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT jobertrichienansseu insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT vickyjocelynemoorama insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT jeanjoelbigna insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT felixkembeassah insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT magellanguewofokeng insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT steveleumi insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT jeanclaudekatte insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT mesmindehayem insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT andrepascalkengne insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon AT eugenesobngwi insulinresistanceandassociatedfactorsamonghivinfectedpatientsinsubsaharanafricaacrosssectionalstudyfromcameroon |
_version_ |
1725946817681555456 |