Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer
Abstract Background The long‐term health‐related quality of life (HRQOL) impacts of PCa screening have not been adequately evaluated. We aimed to compare the generic and disease‐specific health‐related quality of life (HRQOL) among men with prostate cancer in the screening arm with the control arm o...
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doaj-688d1116440f48aabeee866f4945aa042020-11-25T02:58:22ZengWileyCancer Medicine2045-76342020-08-019155643565410.1002/cam4.3181Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancerKirsi Talala0Sirpa Heinävaara1Kimmo Taari2Teuvo L. J. Tammela3Paula Kujala4Ulf‐Håkan Stenman5Nea Malila6Anssi Auvinen7Finnish Cancer Registry Helsinki FinlandFinnish Cancer Registry Helsinki FinlandDepartment of Urology University of Helsinki and Helsinki University Hospital Helsinki FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandDepartment of Pathology Fimlab Laboratories Tampere FinlandDepartment of Clinical Chemistry and Hematology Faculty of Medicine University of Helsinki Helsinki FinlandFinnish Cancer Registry Helsinki FinlandFaculty of Social Sciences/Health Sciences Tampere University Tampere FinlandAbstract Background The long‐term health‐related quality of life (HRQOL) impacts of PCa screening have not been adequately evaluated. We aimed to compare the generic and disease‐specific health‐related quality of life (HRQOL) among men with prostate cancer in the screening arm with the control arm of the PSA‐based prostate cancer screening trial in up to 15 years of follow‐up. Materials and methods This study was conducted within population‐based Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). During 1996‐1999 80,458 men were randomized to the serum prostate‐specific antigen (PSA) screening arm (SA, N = 32 000) and the control arm (CA, N = 48 458). Men in the screening arm were screened at 4‐year intervals until 2007. HRQOL questionnaires were delivered to newly diagnosed prostate cancer patients in the screening and control arm 1996‐2006 (N = 5128) at the time of diagnosis (baseline), at 3‐month, 12‐month and 5, 10, and 15‐year follow‐up. Validated UCLA Prostate Cancer Index (UCLA‐PCI) and RAND 36‐Item Health Survey were used for HRQOL assessment. The data were analyzed with a random effects model for repeated measures. Results At baseline, men with prostate cancer in the screening arm reported better Sexual Function, as well as less Sexual and Urinary Bother. Long‐term follow‐up revealed slightly higher HRQOL scores in the screening arm in prostate cancer specific measures at 10‐year post diagnosis, but the differences were statistically significant only in Urinary Bother (UCLA‐PCI score 77.9; 95% CI 75.2 to 80.5 vs. 70.9; 95% CI 66.8 to 74.9 P = .005). The generic HRQOL scores were comparable between the trial arms. The overall differences in disease‐specific or generic HRQOL scores by trial arm did not vary during the follow‐up. Conclusion No major differences were observed in HRQOL in men with prostate cancer between the prostate cancer screening and control arms during five to 15‐year follow‐up.https://doi.org/10.1002/cam4.3181prostate cancerquality of lifescreening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kirsi Talala Sirpa Heinävaara Kimmo Taari Teuvo L. J. Tammela Paula Kujala Ulf‐Håkan Stenman Nea Malila Anssi Auvinen |
spellingShingle |
Kirsi Talala Sirpa Heinävaara Kimmo Taari Teuvo L. J. Tammela Paula Kujala Ulf‐Håkan Stenman Nea Malila Anssi Auvinen Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer Cancer Medicine prostate cancer quality of life screening |
author_facet |
Kirsi Talala Sirpa Heinävaara Kimmo Taari Teuvo L. J. Tammela Paula Kujala Ulf‐Håkan Stenman Nea Malila Anssi Auvinen |
author_sort |
Kirsi Talala |
title |
Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer |
title_short |
Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer |
title_full |
Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer |
title_fullStr |
Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer |
title_full_unstemmed |
Long‐term health‐related quality of life among men with prostate cancer in the Finnish randomized study of screening for prostate cancer |
title_sort |
long‐term health‐related quality of life among men with prostate cancer in the finnish randomized study of screening for prostate cancer |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2020-08-01 |
description |
Abstract Background The long‐term health‐related quality of life (HRQOL) impacts of PCa screening have not been adequately evaluated. We aimed to compare the generic and disease‐specific health‐related quality of life (HRQOL) among men with prostate cancer in the screening arm with the control arm of the PSA‐based prostate cancer screening trial in up to 15 years of follow‐up. Materials and methods This study was conducted within population‐based Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). During 1996‐1999 80,458 men were randomized to the serum prostate‐specific antigen (PSA) screening arm (SA, N = 32 000) and the control arm (CA, N = 48 458). Men in the screening arm were screened at 4‐year intervals until 2007. HRQOL questionnaires were delivered to newly diagnosed prostate cancer patients in the screening and control arm 1996‐2006 (N = 5128) at the time of diagnosis (baseline), at 3‐month, 12‐month and 5, 10, and 15‐year follow‐up. Validated UCLA Prostate Cancer Index (UCLA‐PCI) and RAND 36‐Item Health Survey were used for HRQOL assessment. The data were analyzed with a random effects model for repeated measures. Results At baseline, men with prostate cancer in the screening arm reported better Sexual Function, as well as less Sexual and Urinary Bother. Long‐term follow‐up revealed slightly higher HRQOL scores in the screening arm in prostate cancer specific measures at 10‐year post diagnosis, but the differences were statistically significant only in Urinary Bother (UCLA‐PCI score 77.9; 95% CI 75.2 to 80.5 vs. 70.9; 95% CI 66.8 to 74.9 P = .005). The generic HRQOL scores were comparable between the trial arms. The overall differences in disease‐specific or generic HRQOL scores by trial arm did not vary during the follow‐up. Conclusion No major differences were observed in HRQOL in men with prostate cancer between the prostate cancer screening and control arms during five to 15‐year follow‐up. |
topic |
prostate cancer quality of life screening |
url |
https://doi.org/10.1002/cam4.3181 |
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