Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01169-0 |
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doaj-688d3e51bd6e4384bf9ccbf1181bb7d62021-05-11T07:46:19ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-01169-0Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesisNeil P. Dufton0Claire R. Peghaire1Lourdes Osuna-Almagro2Claudio Raimondi3Viktoria Kalna4Abhishek Chauhan5Gwilym Webb6Youwen Yang7Graeme M. Birdsey8Patricia Lalor9Justin C. Mason10David H. Adams11Anna M. Randi12Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonCentre for Liver Research, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamCentre for Liver Research, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonCentre for Liver Research, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonCentre for Liver Research, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of BirminghamVascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College LondonThe transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent mechanism.https://doi.org/10.1038/s41467-017-01169-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi |
| spellingShingle |
Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis Nature Communications |
| author_facet |
Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi |
| author_sort |
Neil P. Dufton |
| title |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis |
| title_short |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis |
| title_full |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis |
| title_fullStr |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis |
| title_full_unstemmed |
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis |
| title_sort |
dynamic regulation of canonical tgfβ signalling by endothelial transcription factor erg protects from liver fibrogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent mechanism. |
| url |
https://doi.org/10.1038/s41467-017-01169-0 |
| work_keys_str_mv |
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