Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients
Objectives: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between pat...
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doaj-68938499da264594b36aee3cf9f5455f2020-11-25T03:31:56ZengElsevierBrazilian Journal of Infectious Diseases1413-86702013-03-01172150155Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patientsDenise Cerqueira Paranaguá Vezozzo0Maria Cassia Mendes-Correa1Marlone Cunha-Silva2Mónica Viviana Alvarado-Mora3João Ítalo Dias França4José Luiz Sebba5Antonio Carlos Nicodemo6Claudia P.M.S. Oliveira7Flair José Carrilho8Department of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil; Corresponding author at: Hepatology Branch, Department of Gastroenterology, Medical School, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 São Paulo, SP 05403-000, Brazil.Department of Infectious Diseases, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Infectious Diseases, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Gastroenterology, Medical School, Universidade de São Paulo, São Paulo, SP, BrazilObjectives: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between patients with human immunodeficiency virus/hepatitis C virus co-infection (n = 16) versus hepatitis C virus mono-infection (n = 16). Methods: Each patient underwent abdominal ultrasound, and a specific evaluation was performed in order to detect findings consistent with chronic liver disease. Characterization of spleen size, liver structural pattern, diameter of the portal, spleen, and mesenteric veins was based on classical ultrasound parameters. Propensity score was used for control of selection bias and performed using binary logistic regression to generate a score for each patient. The Fisher and Mann–Whitney tests were used to evaluate categorical variables and continuous variables, respectively. Results: On univariate analysis right hepatic lobe size was larger in human immunodeficiency virus/hepatitis C virus patients (157.06 ± 17.56 mm) compared to hepatitis C virus mono-infected patients (134.94 ± 16.95 mm) (p = 0.0011). The left hepatic lobe was also significantly larger in human immunodeficiency virus/hepatitis C virus patients (115.88 ± 22.69 mm) versus hepatitis C virus mono-infected patients (95.06 ± 24.18 mm) (p = 0.0177). Also, there was a strong correlation between hepatomegaly and co-infection (p = 0.005). Conclusion: Human immunodeficiency virus infection was the primary variable influencing liver enlargement in this population. Hepatomegaly on ultrasound was more common among cirrhotic human immunodeficiency virus/hepatitis C virus co-infected patients than among cirrhotic hepatitis C virus mono-infected patients. This aspect is very important in the management of human immunodeficiency virus/hepatitis C virus co-infected patients, because screening for hepatocellular carcinoma is necessary in this population. Keywords: Ultrasonography, HIV/HCV co-infection, Hepatomegaly, Liver size, Cirrhosishttp://www.sciencedirect.com/science/article/pii/S1413867013000251 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Denise Cerqueira Paranaguá Vezozzo Maria Cassia Mendes-Correa Marlone Cunha-Silva Mónica Viviana Alvarado-Mora João Ítalo Dias França José Luiz Sebba Antonio Carlos Nicodemo Claudia P.M.S. Oliveira Flair José Carrilho |
spellingShingle |
Denise Cerqueira Paranaguá Vezozzo Maria Cassia Mendes-Correa Marlone Cunha-Silva Mónica Viviana Alvarado-Mora João Ítalo Dias França José Luiz Sebba Antonio Carlos Nicodemo Claudia P.M.S. Oliveira Flair José Carrilho Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients Brazilian Journal of Infectious Diseases |
author_facet |
Denise Cerqueira Paranaguá Vezozzo Maria Cassia Mendes-Correa Marlone Cunha-Silva Mónica Viviana Alvarado-Mora João Ítalo Dias França José Luiz Sebba Antonio Carlos Nicodemo Claudia P.M.S. Oliveira Flair José Carrilho |
author_sort |
Denise Cerqueira Paranaguá Vezozzo |
title |
Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients |
title_short |
Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients |
title_full |
Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients |
title_fullStr |
Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients |
title_full_unstemmed |
Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients |
title_sort |
strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in hiv/hcv cirrhotic patients |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2013-03-01 |
description |
Objectives: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between patients with human immunodeficiency virus/hepatitis C virus co-infection (n = 16) versus hepatitis C virus mono-infection (n = 16). Methods: Each patient underwent abdominal ultrasound, and a specific evaluation was performed in order to detect findings consistent with chronic liver disease. Characterization of spleen size, liver structural pattern, diameter of the portal, spleen, and mesenteric veins was based on classical ultrasound parameters. Propensity score was used for control of selection bias and performed using binary logistic regression to generate a score for each patient. The Fisher and Mann–Whitney tests were used to evaluate categorical variables and continuous variables, respectively. Results: On univariate analysis right hepatic lobe size was larger in human immunodeficiency virus/hepatitis C virus patients (157.06 ± 17.56 mm) compared to hepatitis C virus mono-infected patients (134.94 ± 16.95 mm) (p = 0.0011). The left hepatic lobe was also significantly larger in human immunodeficiency virus/hepatitis C virus patients (115.88 ± 22.69 mm) versus hepatitis C virus mono-infected patients (95.06 ± 24.18 mm) (p = 0.0177). Also, there was a strong correlation between hepatomegaly and co-infection (p = 0.005). Conclusion: Human immunodeficiency virus infection was the primary variable influencing liver enlargement in this population. Hepatomegaly on ultrasound was more common among cirrhotic human immunodeficiency virus/hepatitis C virus co-infected patients than among cirrhotic hepatitis C virus mono-infected patients. This aspect is very important in the management of human immunodeficiency virus/hepatitis C virus co-infected patients, because screening for hepatocellular carcinoma is necessary in this population. Keywords: Ultrasonography, HIV/HCV co-infection, Hepatomegaly, Liver size, Cirrhosis |
url |
http://www.sciencedirect.com/science/article/pii/S1413867013000251 |
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