IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS
The in vitro action of some new autochthonous glucanic biopreparations, specifically extracted from diverse submerged strains of Claviceps purpurea, upon the proteinsynthesis of Hep-2p cancerous cells as well as upon the development of the corresponding cellular cultures was investigated. The signif...
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"Alexandru Ioan Cuza" University of Iași
2008-02-01
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Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/566 |
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doaj-689731566a0e475d9c7a47c595d2eb302020-11-25T00:14:22Zeng"Alexandru Ioan Cuza" University of IașiAnalele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara 1582-35712248-32762008-02-0191559IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTSCosmin MihaiPincu RotinbergDaniela GherghelGabriela CapraruTruta ElenaSurdu StefaniaOlteanu ZenoviaHellen RotinbergThe in vitro action of some new autochthonous glucanic biopreparations, specifically extracted from diverse submerged strains of Claviceps purpurea, upon the proteinsynthesis of Hep-2p cancerous cells as well as upon the development of the corresponding cellular cultures was investigated. The significant perturbation of proteic biogenesis, the modification of the protein dynamics, the inhibition of the cell cultures development and the existence of a doseresponse relationship argue the behaviour of the low intensity and frequency electromagnetic field as in vitro active cytostatic agent. This primary characterization of some glucanic extracts as cytostatic agent justifies the study of their effect upon cell proliferation and viability in order to enlarge the reasoning basis for the introduction of those exopolysaccharidic agents in the in vivo antitumoral screening program on different experimental tumoral systems.http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/566 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cosmin Mihai Pincu Rotinberg Daniela Gherghel Gabriela Capraru Truta Elena Surdu Stefania Olteanu Zenovia Hellen Rotinberg |
spellingShingle |
Cosmin Mihai Pincu Rotinberg Daniela Gherghel Gabriela Capraru Truta Elena Surdu Stefania Olteanu Zenovia Hellen Rotinberg IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
author_facet |
Cosmin Mihai Pincu Rotinberg Daniela Gherghel Gabriela Capraru Truta Elena Surdu Stefania Olteanu Zenovia Hellen Rotinberg |
author_sort |
Cosmin Mihai |
title |
IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS |
title_short |
IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS |
title_full |
IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS |
title_fullStr |
IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS |
title_full_unstemmed |
IN VITRO SELECTION OF SOME POTENTIAL CYTOSTATIC AGENTS FROM NEW FUNGAL EXOPOLYGLUCIDIC EXTRACTS |
title_sort |
in vitro selection of some potential cytostatic agents from new fungal exopolyglucidic extracts |
publisher |
"Alexandru Ioan Cuza" University of Iași |
series |
Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
issn |
1582-3571 2248-3276 |
publishDate |
2008-02-01 |
description |
The in vitro action of some new autochthonous glucanic biopreparations, specifically extracted from diverse
submerged strains of Claviceps purpurea, upon the proteinsynthesis of Hep-2p cancerous cells as well as upon the
development of the corresponding cellular cultures was investigated. The significant perturbation of proteic biogenesis,
the modification of the protein dynamics, the inhibition of the cell cultures development and the existence of a doseresponse
relationship argue the behaviour of the low intensity and frequency electromagnetic field as in vitro active
cytostatic agent. This primary characterization of some glucanic extracts as cytostatic agent justifies the study of their
effect upon cell proliferation and viability in order to enlarge the reasoning basis for the introduction of those
exopolysaccharidic agents in the in vivo antitumoral screening program on different experimental tumoral systems. |
url |
http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/566 |
work_keys_str_mv |
AT cosminmihai invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT pincurotinberg invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT danielagherghel invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT gabrielacapraru invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT trutaelena invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT surdustefania invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT olteanuzenovia invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts AT hellenrotinberg invitroselectionofsomepotentialcytostaticagentsfromnewfungalexopolyglucidicextracts |
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