Physico-chemical studies on binary aqueous solutions of Anti-Viral Influenza drugs

• Main Authors: S. Punitha, R. Uvarani, A. Panneerselvam, S. Nithiyanantham
• Format: Article
• Language: English
• Published: Elsevier 2019-06-01
• Series: Heliyon
• Subjects: Pharmaceutical science; Physical chemistry; Pharmaceutical chemistry influenza anti-viral drugs; HPMC; Lactose; Calcium chloride
• Online Access: http://www.sciencedirect.com/science/article/pii/S2405844018377946

The ultrasonic velocity, density, viscosity and absorption have been measured for solution of Influenza Anti-Viral drugs (Amantadine and Oseltamivir) are presented at room temperature 303K. By taking measurements of Anti Influenza Viral drugs at 0.2, 0.4 and 0.6% concentrations of each solution. The aim of the study is to increase the solubility, stability, sweetness of drugs by the formation of complexation. The ultrasonic velocity, density and viscosity have been measured at 2MHz for the aqueous solutions of (i) Influenza Anti-Viral Drugs + HPMC (Hydroxy Propyl Methyl Cellulose), Lactose and CaCl2 (Calcium Chloride at different concentrations at a temperature 303K.The acoustical parameters such as adiabatic compressibility (β), intermolecular free length (Lf), internal pressure (πi), Rao's constant (R), relaxation time (τ), acoustical impedance (Za), absorption coefficient (α/f2), free volume (Vf), cohesive energy and solvation number (Sn) have been computed. These properties are attributed to solute-solvent interactions through hydrogen bonding, segment-segment interaction, molecular association, polymer-solvent interaction, polymer-polymer interaction and etc. The total absorption can be considered as the sum of contributions from solute-solvent interactions. These results are further supported by FTIR studies.