LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.
Bibliographic Details
Main Authors: |
Eun-Jin Bae,
Dong-Kyu Kim,
Changyoun Kim,
Michael Mante,
Anthony Adame,
Edward Rockenstein,
Ayse Ulusoy,
Michael Klinkenberg,
Ga Ram Jeong,
Jae Ryul Bae,
Cheolsoon Lee,
He-Jin Lee,
Byung-Dae Lee,
Donato A. Di Monte,
Eliezer Masliah,
Seung-Jae Lee |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-05958-z
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