Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
Abstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chro...
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doaj-68bd99ae1ac54a11b607c103c75f02d62020-12-08T00:30:00ZengNature Publishing GroupScientific Reports2045-23222017-03-01711710.1038/s41598-017-00463-7Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary studyChao Wang0Zhujing Shen1Peiyu Huang2Hualiang Yu3Wei Qian4Xiaojun Guan5Quanquan Gu6Yihong Yang7Minming Zhang8Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Psychiatry, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of HealthDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chronic smokers. The aim of this study was to investigate alterations of brain activity during the resting state in chronic smokers using fractional amplitude of low-frequency fluctuation (fALFF). In the present study, 55 smokers and 49 healthy nonsmokers were included. All the subjects underwent resting-state fMRI scans and the data were analyzed by the fALFF approach. The smokers showed significantly decreased fALFF in the left precuneus, right inferior temporal and occipital gyrus(ITG/IOG), while significantly increased fALFF in the right caudate. Subsequent correlation analysis revealed that the fALFF values of the left precuneus and right ITG/IOG were positively correlated with years of smoking across the smokers. This resting-state fMRI study suggests that the changed spontaneous neuronal activity, as reflected by the fALFF, in these regions may be implicated in the underlying the pathophysiology of smoking.https://doi.org/10.1038/s41598-017-00463-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao Wang Zhujing Shen Peiyu Huang Hualiang Yu Wei Qian Xiaojun Guan Quanquan Gu Yihong Yang Minming Zhang |
spellingShingle |
Chao Wang Zhujing Shen Peiyu Huang Hualiang Yu Wei Qian Xiaojun Guan Quanquan Gu Yihong Yang Minming Zhang Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study Scientific Reports |
author_facet |
Chao Wang Zhujing Shen Peiyu Huang Hualiang Yu Wei Qian Xiaojun Guan Quanquan Gu Yihong Yang Minming Zhang |
author_sort |
Chao Wang |
title |
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
title_short |
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
title_full |
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
title_fullStr |
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
title_full_unstemmed |
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
title_sort |
altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-03-01 |
description |
Abstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chronic smokers. The aim of this study was to investigate alterations of brain activity during the resting state in chronic smokers using fractional amplitude of low-frequency fluctuation (fALFF). In the present study, 55 smokers and 49 healthy nonsmokers were included. All the subjects underwent resting-state fMRI scans and the data were analyzed by the fALFF approach. The smokers showed significantly decreased fALFF in the left precuneus, right inferior temporal and occipital gyrus(ITG/IOG), while significantly increased fALFF in the right caudate. Subsequent correlation analysis revealed that the fALFF values of the left precuneus and right ITG/IOG were positively correlated with years of smoking across the smokers. This resting-state fMRI study suggests that the changed spontaneous neuronal activity, as reflected by the fALFF, in these regions may be implicated in the underlying the pathophysiology of smoking. |
url |
https://doi.org/10.1038/s41598-017-00463-7 |
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