CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study
Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate do...
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doaj-68c2c47272044677a5cd8b3f4bebac952020-11-24T23:06:45ZengMDPI AGNutrients2072-66432017-03-019326910.3390/nu9030269nu9030269CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot StudyJuan J. Salinero0Beatriz Lara1Diana Ruiz-Vicente2Francisco Areces3Carlos Puente-Torres4César Gallo-Salazar5Teodoro Pascual6Juan Del Coso7Exercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainExercise Physiology Laboratory, Camilo José Cela University, Madrid 28692, SpainPrevious investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants (29.3 ± 7.7 years) ingested 3 mg of caffeine per kg of body mass or a placebo in testing sessions separated by one week. Performance in the 30 s Wingate test, visual attention, and side effects were evaluated. DNA was obtained from whole blood samples and the CYP1A2 polymorphism was analyzed (rs762551). We obtained two groups: AA homozygotes (n = 5) and C-allele carriers (n = 16). Caffeine ingestion increased peak power (682 ± 140 vs. 667 ± 137 W; p = 0.008) and mean power during the Wingate test (527 ± 111 vs. 518 ± 111 W; p < 0.001) with no differences between AA homozygotes and C-allele carriers (p > 0.05). Reaction times were similar between caffeine and placebo conditions (276 ± 31 vs. 269 ± 71 milliseconds; p = 0.681) with no differences between AA homozygotes and C-allele carriers. However, 31.3% of the C-allele carriers reported increased nervousness after caffeine ingestion, while none of the AA homozygotes perceived this side effect. Genetic variations of the CYP1A2 polymorphism did not affect the ergogenic effects and drawbacks derived from the ingestion of a moderate dose of caffeine.http://www.mdpi.com/2072-6643/9/3/269geneticscyclingergogenic aidside effectsperformance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan J. Salinero Beatriz Lara Diana Ruiz-Vicente Francisco Areces Carlos Puente-Torres César Gallo-Salazar Teodoro Pascual Juan Del Coso |
spellingShingle |
Juan J. Salinero Beatriz Lara Diana Ruiz-Vicente Francisco Areces Carlos Puente-Torres César Gallo-Salazar Teodoro Pascual Juan Del Coso CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study Nutrients genetics cycling ergogenic aid side effects performance |
author_facet |
Juan J. Salinero Beatriz Lara Diana Ruiz-Vicente Francisco Areces Carlos Puente-Torres César Gallo-Salazar Teodoro Pascual Juan Del Coso |
author_sort |
Juan J. Salinero |
title |
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study |
title_short |
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study |
title_full |
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study |
title_fullStr |
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study |
title_full_unstemmed |
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study |
title_sort |
cyp1a2 genotype variations do not modify the benefits and drawbacks of caffeine during exercise: a pilot study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-03-01 |
description |
Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants (29.3 ± 7.7 years) ingested 3 mg of caffeine per kg of body mass or a placebo in testing sessions separated by one week. Performance in the 30 s Wingate test, visual attention, and side effects were evaluated. DNA was obtained from whole blood samples and the CYP1A2 polymorphism was analyzed (rs762551). We obtained two groups: AA homozygotes (n = 5) and C-allele carriers (n = 16). Caffeine ingestion increased peak power (682 ± 140 vs. 667 ± 137 W; p = 0.008) and mean power during the Wingate test (527 ± 111 vs. 518 ± 111 W; p < 0.001) with no differences between AA homozygotes and C-allele carriers (p > 0.05). Reaction times were similar between caffeine and placebo conditions (276 ± 31 vs. 269 ± 71 milliseconds; p = 0.681) with no differences between AA homozygotes and C-allele carriers. However, 31.3% of the C-allele carriers reported increased nervousness after caffeine ingestion, while none of the AA homozygotes perceived this side effect. Genetic variations of the CYP1A2 polymorphism did not affect the ergogenic effects and drawbacks derived from the ingestion of a moderate dose of caffeine. |
topic |
genetics cycling ergogenic aid side effects performance |
url |
http://www.mdpi.com/2072-6643/9/3/269 |
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