A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In...
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doaj-68c8ab7ccd964ba0ab445676d1df38382020-11-24T23:05:07ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/45671464567146A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound HealingChizuru Jinno0Naoki Morimoto1Ran Ito2Michiharu Sakamoto3Shuichi Ogino4Tsuguyoshi Taira5Shigehiko Suzuki6Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata City, Osaka 573-1010, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, JapanGUNZE Ltd. QOL Research Center Laboratory, 1 Ishiburo, Inokura Shinmachi, Ayabe, Kyoto 623-8512, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, JapanThe objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared 8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm2 of bFGF solution and implanted into the defects. At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group (n=3, total n=24). The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation. There were no significant differences in the CGS without bFGF and CS groups. Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF. The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.http://dx.doi.org/10.1155/2016/4567146 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chizuru Jinno Naoki Morimoto Ran Ito Michiharu Sakamoto Shuichi Ogino Tsuguyoshi Taira Shigehiko Suzuki |
spellingShingle |
Chizuru Jinno Naoki Morimoto Ran Ito Michiharu Sakamoto Shuichi Ogino Tsuguyoshi Taira Shigehiko Suzuki A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing BioMed Research International |
author_facet |
Chizuru Jinno Naoki Morimoto Ran Ito Michiharu Sakamoto Shuichi Ogino Tsuguyoshi Taira Shigehiko Suzuki |
author_sort |
Chizuru Jinno |
title |
A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing |
title_short |
A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing |
title_full |
A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing |
title_fullStr |
A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing |
title_full_unstemmed |
A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing |
title_sort |
comparison of conventional collagen sponge and collagen-gelatin sponge in wound healing |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared 8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm2 of bFGF solution and implanted into the defects. At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group (n=3, total n=24). The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation. There were no significant differences in the CGS without bFGF and CS groups. Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF. The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs. |
url |
http://dx.doi.org/10.1155/2016/4567146 |
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