Engineering Sub-Cellular Targeting Strategies to Enhance Safe Cytosolic Silica Particle Dissolution in Cells

Engineering Sub-Cellular Targeting Strategies to Enhance Safe Cytosolic Silica Particle Dissolution in Cells

Mesoporous silica particles (MSP) are major candidates for drug delivery systems due to their versatile, safe, and controllable nature. Understanding their intracellular route and biodegradation process is a challenge, especially when considering their use in neuronal repair. Here, we characterize t...

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Bibliographic Details
Main Authors: Nerea Iturrioz-Rodríguez, Miguel Ángel Correa-Duarte, Rafael Valiente, Mónica L. Fanarraga
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
silica nanocarrier
cytoplasmic escape
biodegradation
engineering nanoparticles
HeLa
motor neurons
Online Access:https://www.mdpi.com/1999-4923/12/6/487

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