In silico analysis revealed high-risk single nucleotide polymorphisms in human pentraxin-3 gene and their impact on innate immune response against microbial pathogens

In silico analysis revealed high-risk single nucleotide polymorphisms in human pentraxin-3 gene and their impact on innate immune response against microbial pathogens

Pentraxin-3 (PTX-3) protein is an evolutionary conserved protein that acts as a soluble pattern-recognition receptor for pathogens and plays important role in innate immune response. It recognizes various pathogens by interacting with extracellular moieties such as glactomannan of conidia (Aspergill...

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Bibliographic Details
Main Authors: Raman eThakur, Jata eShankar
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
lipopolysaccharide
In-silico
Galactomannan
nsSNPs
PTX-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00192/full

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