α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease
Parkinson’s disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked mole...
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doaj-68ea38e2ea504eee91921921337b1c542020-11-24T22:22:36ZengMDPI AGInternational Journal of Molecular Sciences1422-00672010-10-0111114257426610.3390/ijms11114257α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s DiseaseMakoto HashimotoMasayo FujitaYoshiki TakamatsuAkio SekigawaKazunari SekiyamaMasaaki WaragaiParkinson’s disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, α-synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may be altered during the progression of PD. In this regard, sensitive and accurate methods for evaluation of α-synuclein and DJ-1 levels in the CSF and blood have been developed, and the results suggest that the levels of both molecules are significantly decreased in the CSF in patients with PD compared with age-matched controls. Furthermore, specific detection and quantification of neurotoxic oligometric forms of α-synuclein in the blood using enzyme-linked immunosorbent assays might be expected as potential peripheral biomarkers for PD, although further validation is required. Currently, neither α-synuclein nor DJ-1 is satisfactory as a single biomarker for PD, but combinatory evaluation of these biological fluid molecules with other biomarkers and imaging techniques may provide reliable information for diagnosis of PD. http://www.mdpi.com/1422-0067/11/11/4257/Parkinson’s diseasecerebrospinal fluidbiomarkerα-synucleinDJ-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Makoto Hashimoto Masayo Fujita Yoshiki Takamatsu Akio Sekigawa Kazunari Sekiyama Masaaki Waragai |
spellingShingle |
Makoto Hashimoto Masayo Fujita Yoshiki Takamatsu Akio Sekigawa Kazunari Sekiyama Masaaki Waragai α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease International Journal of Molecular Sciences Parkinson’s disease cerebrospinal fluid biomarker α-synuclein DJ-1 |
author_facet |
Makoto Hashimoto Masayo Fujita Yoshiki Takamatsu Akio Sekigawa Kazunari Sekiyama Masaaki Waragai |
author_sort |
Makoto Hashimoto |
title |
α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease |
title_short |
α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease |
title_full |
α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease |
title_fullStr |
α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease |
title_full_unstemmed |
α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease |
title_sort |
α-synuclein and dj-1 as potential biological fluid biomarkers for parkinson’s disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2010-10-01 |
description |
Parkinson’s disease (PD) is the most common form of movement disorder and affects approximately 4% of the population aged over 80 years old. Currently, PD cannot be prevented or cured, and no single diagnostic biomarkers are available. Notably, recent studies suggest that two familial PD-linked molecules, α-synuclein and DJ-1, are present in cerebrospinal fluid (CSF) and that their levels may be altered during the progression of PD. In this regard, sensitive and accurate methods for evaluation of α-synuclein and DJ-1 levels in the CSF and blood have been developed, and the results suggest that the levels of both molecules are significantly decreased in the CSF in patients with PD compared with age-matched controls. Furthermore, specific detection and quantification of neurotoxic oligometric forms of α-synuclein in the blood using enzyme-linked immunosorbent assays might be expected as potential peripheral biomarkers for PD, although further validation is required. Currently, neither α-synuclein nor DJ-1 is satisfactory as a single biomarker for PD, but combinatory evaluation of these biological fluid molecules with other biomarkers and imaging techniques may provide reliable information for diagnosis of PD. |
topic |
Parkinson’s disease cerebrospinal fluid biomarker α-synuclein DJ-1 |
url |
http://www.mdpi.com/1422-0067/11/11/4257/ |
work_keys_str_mv |
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