Comparing the Efficacy of a Microperforated Titanium Membrane for Guided Bone Regeneration with an Existing Mesh Retainer in Dog Mandibles

• Main Authors: Hiroshi Hasegawa, Tetsuharu Kaneko, Manabu Endo, Chihiro Kanno, Morio Yamazaki, Sadanoshin Yaginuma, Hiroki Igarashi, Hideaki Honma, Seiichiro Masui, Mizuki Suto, Yukihiko Sakisaka, Hiroshi Ishihata
• Format: Article
• Language: English
• Published: MDPI AG 2021-06-01
• Series: Materials
• Subjects: guided bone regeneration; titanium membrane; barrier membrane; microporous titanium
• Online Access: https://www.mdpi.com/1996-1944/14/12/3358

Acute-type lateral ridge defects (25 mm × 6 mm × 5 mm) were bilaterally created in the mandibles of four dogs (two defects per animal). The defects were reconstructed with particulate autologous bone and covered with a microperforated titanium membrane (Ti-honeycomb membrane, TiHM) or an existing conventional titanium mesh as control. The samples were dissected after 16 weeks postoperatively and processed for radiographic, histologic, and histomorphometric analyses. Regenerated tissue and bone volume were significantly larger in the TiHM group than in the control group (<i>p</i> = 0.05; <i>p</i> = 0.049). In contrast, bone mineral density was similar between the two groups. Histomorphometric analysis revealed that the regenerated bone area and calcific osseous area were larger in the TiHM group than in the control group; however, the differences were not significant. The efficacy of TiHM was generally satisfactory with the potential to become a standard tool for the GBR procedure; however, early membrane exposure will be a major problem to overcome.