Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis
Abstract Background Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-08-01
|
Series: | BMC Surgery |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12893-020-00848-y |
id |
doaj-68efa4b78a64488183cabc1e6ec8e0f4 |
---|---|
record_format |
Article |
spelling |
doaj-68efa4b78a64488183cabc1e6ec8e0f42020-11-25T03:25:48ZengBMCBMC Surgery1471-24822020-08-012011810.1186/s12893-020-00848-yObesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysisCelestin Danwang0Valirie Ndip Agbor1Jean Joel Bigna2Epidemiology and Biostatistics Unit, Institute of Experimental and Clinical Research, Université Catholique de LouvainClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of OxfordDepartment of Epidemiology and Public Health, Centre Pasteur of CameroonAbstract Background Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate the association between obesity and outcomes of patients after laparoscopic adrenalectomy. Methods We searched EMBASE, PubMed, Global Index Medicus, and Web of Science, without language restriction, to identify cohort studies published between January 1, 2000 and November 6, 2019. We considered studies with data comparing outcomes of adults with and without obesity after laparoscopic adrenalectomy. Random-effects meta-analysis was used to pool study-specific estimates. This review was registered with PROSPERO, CRD42018117070. Results Five studies with data on a pooled sample of 353 patients with obesity and 828 without were included in the meta-analysis. The risk of bias was moderate to low. We found no association between obesity and the various stages of postoperative complications: Clavien-Dindo grade 1 (OR = 1.57; 95%CI = 0.55–4.48; I2 = 44.6%), grade 2 (OR = 1.12; 95%CI = 0.54–2.32; I2 = 0.0%), grade 3 (OR = 1.79; 95%CI = 0.58–5.47; I2 = 0.0%;), grade 4 (OR = 0.43; 95%CI = 0.05–3.71; I2 = 0.0%), and grade 5 (death) (OR = 0.43; 95% CI = 0.02–14.31). Furthermore, no association was found between obesity and readmission rates (OR = 0.7; 95% CI = 0.13–3.62) and conversion of laparoscopic to open surgery (OR = 0.62; 95% CI = 0.16–2.34; I2 = 19.5%). Conclusions This study suggests that obesity is not associated with complications following laparoscopic adrenalectomy. This meta-analysis might have been underpowered to detect a true association between obesity and patient outcome after laparoscopic adrenalectomy due to the small number of included studies. Larger studies are needed to clarify the role of obesity in patients undergoing laparoscopic adrenalectomy.http://link.springer.com/article/10.1186/s12893-020-00848-yLaparoscopyAdrenalectomyObesityOutcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Celestin Danwang Valirie Ndip Agbor Jean Joel Bigna |
spellingShingle |
Celestin Danwang Valirie Ndip Agbor Jean Joel Bigna Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis BMC Surgery Laparoscopy Adrenalectomy Obesity Outcome |
author_facet |
Celestin Danwang Valirie Ndip Agbor Jean Joel Bigna |
author_sort |
Celestin Danwang |
title |
Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_short |
Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_full |
Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_fullStr |
Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_full_unstemmed |
Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_sort |
obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
publisher |
BMC |
series |
BMC Surgery |
issn |
1471-2482 |
publishDate |
2020-08-01 |
description |
Abstract Background Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate the association between obesity and outcomes of patients after laparoscopic adrenalectomy. Methods We searched EMBASE, PubMed, Global Index Medicus, and Web of Science, without language restriction, to identify cohort studies published between January 1, 2000 and November 6, 2019. We considered studies with data comparing outcomes of adults with and without obesity after laparoscopic adrenalectomy. Random-effects meta-analysis was used to pool study-specific estimates. This review was registered with PROSPERO, CRD42018117070. Results Five studies with data on a pooled sample of 353 patients with obesity and 828 without were included in the meta-analysis. The risk of bias was moderate to low. We found no association between obesity and the various stages of postoperative complications: Clavien-Dindo grade 1 (OR = 1.57; 95%CI = 0.55–4.48; I2 = 44.6%), grade 2 (OR = 1.12; 95%CI = 0.54–2.32; I2 = 0.0%), grade 3 (OR = 1.79; 95%CI = 0.58–5.47; I2 = 0.0%;), grade 4 (OR = 0.43; 95%CI = 0.05–3.71; I2 = 0.0%), and grade 5 (death) (OR = 0.43; 95% CI = 0.02–14.31). Furthermore, no association was found between obesity and readmission rates (OR = 0.7; 95% CI = 0.13–3.62) and conversion of laparoscopic to open surgery (OR = 0.62; 95% CI = 0.16–2.34; I2 = 19.5%). Conclusions This study suggests that obesity is not associated with complications following laparoscopic adrenalectomy. This meta-analysis might have been underpowered to detect a true association between obesity and patient outcome after laparoscopic adrenalectomy due to the small number of included studies. Larger studies are needed to clarify the role of obesity in patients undergoing laparoscopic adrenalectomy. |
topic |
Laparoscopy Adrenalectomy Obesity Outcome |
url |
http://link.springer.com/article/10.1186/s12893-020-00848-y |
work_keys_str_mv |
AT celestindanwang obesityandpostoperativeoutcomesofthepatientswithlaparoscopicadrenalectomyasystematicreviewandmetaanalysis AT valiriendipagbor obesityandpostoperativeoutcomesofthepatientswithlaparoscopicadrenalectomyasystematicreviewandmetaanalysis AT jeanjoelbigna obesityandpostoperativeoutcomesofthepatientswithlaparoscopicadrenalectomyasystematicreviewandmetaanalysis |
_version_ |
1724595680298663936 |