The Effect of Anabolic Steroid Boldenone, zizyphus jujube and training on testicular tissue damage in Wistar rats

• Main Authors: majid abbaszadeh, hassan matinhomaee, parvin farzanegi
• Format: Article
• Language: fas
• Published: Neyshabur University of Medical Sciences 2019-03-01
• Series: Majallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr
• Subjects: Anabolic Steroid; Resistance and endurance training; Testicular tissue; Rat
• Online Access: http://journal.nums.ac.ir/browse.php?a_code=A-10-698-3&slc_lang=en&sid=1
• ISSN: 2383-3203; 2476-2768

Introduction The use of anabolic-androgenic steroids by athletes has some effects on the structure and function of the organs of the body, such as the genital system. The purpose of this study was to investigate the effect of anabolic steroid Boldenone, endurance and resistance training on testicular tissue damage in Wistar rats Materials and Methods 77 Wistar rats were randomly divided into the eleven equal groups: control, sham, Boldenone, Gallic acid + Resistance training + Boldenone, Resistance training + Boldenone, Gallic acid + Endurance training + Boldenone, zizyphus jujube + Endurance training + Boldenone, Endurance training + Boldenone, zizyphus jujube + Resistance training + Boldenone, Gallic acid + Boldenone, zizyphus jujube + Boldenone. The resistance exercise protocol consisted of three exercise sessions per week of the climbing ladder for eight weeks, and endurance training for each session 30 minutes at a speed of 12 m / min. Data analysis was performed by two way analysis of variance. Results The highest rate of tissue failure and degenerative changes were observed in the Boldenone group. The diameter and size of the Seminiferoustubules are equal and the base membrane is normal in the Boldenone + zizyphus jujube and Boldenone + Resistance training groups. However, the diameter of the tubes was different for each other in the Boldenone+ endurance training group. Conclusion Boldonone can damage testicular tissue structure and degenerative changes. It is possible that resistance training with jujube supplementation to endurance training can reduce the testicular tissue damage-induced the boldonone injection.