Transcriptional regulators of Na, K-ATPase subunits
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion mo...
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doaj-68f428cc69fb4528a37712722a3855ce2020-11-24T21:59:59ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2015-10-01310.3389/fcell.2015.00066162321Transcriptional regulators of Na, K-ATPase subunitsZhiqin eLi0Sigrid A Langhans1AI duPont Hospital for ChildrenAI duPont Hospital for ChildrenThe Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00066/fullTranscription FactorsCancerepigeneticsNa-K-ATPaseAlpha-subunitbeta-subunit |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhiqin eLi Sigrid A Langhans |
spellingShingle |
Zhiqin eLi Sigrid A Langhans Transcriptional regulators of Na, K-ATPase subunits Frontiers in Cell and Developmental Biology Transcription Factors Cancer epigenetics Na-K-ATPase Alpha-subunit beta-subunit |
author_facet |
Zhiqin eLi Sigrid A Langhans |
author_sort |
Zhiqin eLi |
title |
Transcriptional regulators of Na, K-ATPase subunits |
title_short |
Transcriptional regulators of Na, K-ATPase subunits |
title_full |
Transcriptional regulators of Na, K-ATPase subunits |
title_fullStr |
Transcriptional regulators of Na, K-ATPase subunits |
title_full_unstemmed |
Transcriptional regulators of Na, K-ATPase subunits |
title_sort |
transcriptional regulators of na, k-atpase subunits |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2015-10-01 |
description |
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease. |
topic |
Transcription Factors Cancer epigenetics Na-K-ATPase Alpha-subunit beta-subunit |
url |
http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00066/full |
work_keys_str_mv |
AT zhiqineli transcriptionalregulatorsofnakatpasesubunits AT sigridalanghans transcriptionalregulatorsofnakatpasesubunits |
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