Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis
Inflammasomes are a group of protein complexes that are assembled by pattern recognition receptors following the recognition of invading pathogens or host-derived danger signals. Inflammasomes such as NLRP3 mediate the activation of caspase-1 and the production of the proinflammatory cytokines IL-18...
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doaj-68fe31bf8bf24bca8398c7c9a002e0af2020-11-24T21:26:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-01-01710.3389/fcell.2019.00378503855Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and FibrosisCao Li0Shanshan Guo1Wenyuan Pang2Wenyuan Pang3Zhigang Zhao4Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Pharmacology, School of Pharmaceutical Sciences, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaInflammasomes are a group of protein complexes that are assembled by pattern recognition receptors following the recognition of invading pathogens or host-derived danger signals. Inflammasomes such as NLRP3 mediate the activation of caspase-1 and the production of the proinflammatory cytokines IL-18 and IL-1β. Regulation of inflammasome signaling is critical for host defense against infections and maintenance of cellular homeostasis upon exposure to multiple harmful stimuli. Recent studies have highlighted an important role of acid sphingomyelinase (ASM) in regulating inflammasome activation. ASM hydrolyzes sphingomyelin to ceramide, which further fuses to large ceramide-enriched platforms functioning in stabilizing and amplifying molecules and receptors. Here, we will discuss the current understanding of the ASM-ceramide system in inflammasome activation, and how it contributes to multiple diseases. Insights into such mechanisms would pave the way for further exploration of novel diagnostic, preventative, and therapeutic targets against tissue injury and fibrosis.https://www.frontiersin.org/article/10.3389/fcell.2019.00378/fullacid sphingomyelinaseceramideinflammasomefibrosislysosomeROS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cao Li Shanshan Guo Wenyuan Pang Wenyuan Pang Zhigang Zhao |
spellingShingle |
Cao Li Shanshan Guo Wenyuan Pang Wenyuan Pang Zhigang Zhao Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis Frontiers in Cell and Developmental Biology acid sphingomyelinase ceramide inflammasome fibrosis lysosome ROS |
author_facet |
Cao Li Shanshan Guo Wenyuan Pang Wenyuan Pang Zhigang Zhao |
author_sort |
Cao Li |
title |
Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis |
title_short |
Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis |
title_full |
Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis |
title_fullStr |
Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis |
title_full_unstemmed |
Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis |
title_sort |
crosstalk between acid sphingomyelinase and inflammasome signaling and their emerging roles in tissue injury and fibrosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-01-01 |
description |
Inflammasomes are a group of protein complexes that are assembled by pattern recognition receptors following the recognition of invading pathogens or host-derived danger signals. Inflammasomes such as NLRP3 mediate the activation of caspase-1 and the production of the proinflammatory cytokines IL-18 and IL-1β. Regulation of inflammasome signaling is critical for host defense against infections and maintenance of cellular homeostasis upon exposure to multiple harmful stimuli. Recent studies have highlighted an important role of acid sphingomyelinase (ASM) in regulating inflammasome activation. ASM hydrolyzes sphingomyelin to ceramide, which further fuses to large ceramide-enriched platforms functioning in stabilizing and amplifying molecules and receptors. Here, we will discuss the current understanding of the ASM-ceramide system in inflammasome activation, and how it contributes to multiple diseases. Insights into such mechanisms would pave the way for further exploration of novel diagnostic, preventative, and therapeutic targets against tissue injury and fibrosis. |
topic |
acid sphingomyelinase ceramide inflammasome fibrosis lysosome ROS |
url |
https://www.frontiersin.org/article/10.3389/fcell.2019.00378/full |
work_keys_str_mv |
AT caoli crosstalkbetweenacidsphingomyelinaseandinflammasomesignalingandtheiremergingrolesintissueinjuryandfibrosis AT shanshanguo crosstalkbetweenacidsphingomyelinaseandinflammasomesignalingandtheiremergingrolesintissueinjuryandfibrosis AT wenyuanpang crosstalkbetweenacidsphingomyelinaseandinflammasomesignalingandtheiremergingrolesintissueinjuryandfibrosis AT wenyuanpang crosstalkbetweenacidsphingomyelinaseandinflammasomesignalingandtheiremergingrolesintissueinjuryandfibrosis AT zhigangzhao crosstalkbetweenacidsphingomyelinaseandinflammasomesignalingandtheiremergingrolesintissueinjuryandfibrosis |
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