Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study

• Main Authors: Tongtong Yu, Yundi Jiao, Jia Song, Dongxu He, Jiake Wu, Zhijun Sun, Zhaoqing Sun
• Format: Article
• Language: English
• Published: BMC 2019-11-01
• Series: BMC Cardiovascular Disorders
• Subjects: D-dimer; In-hospital mortality; Acute coronary syndrome; GRACE score; Percutaneous coronary intervention
• Online Access: http://link.springer.com/article/10.1186/s12872-019-1239-4

Abstract Backgroud To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods In 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested. Results After multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035). Conclusion In patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score.