Emerging Roles of BRD7 in Pathophysiology
Bromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, B...
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doaj-690b7201a38943a884ecba78b5358bc62020-11-25T03:54:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01217127712710.3390/ijms21197127Emerging Roles of BRD7 in PathophysiologySang Won Park0Junsik M. Lee1Division of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USADivision of Endocrinology, Boston Children’s Hospital, Boston, MA 02115, USABromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. Decreased BRD7 activity underlies the pathophysiological properties of various diseases in different organs. BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with a focus on glucose homeostasis, obesity, and cancer.https://www.mdpi.com/1422-0067/21/19/7127BRD7glucose metabolismtype 2 diabetesXBP1sPI3Kp85 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sang Won Park Junsik M. Lee |
spellingShingle |
Sang Won Park Junsik M. Lee Emerging Roles of BRD7 in Pathophysiology International Journal of Molecular Sciences BRD7 glucose metabolism type 2 diabetes XBP1s PI3K p85 |
author_facet |
Sang Won Park Junsik M. Lee |
author_sort |
Sang Won Park |
title |
Emerging Roles of BRD7 in Pathophysiology |
title_short |
Emerging Roles of BRD7 in Pathophysiology |
title_full |
Emerging Roles of BRD7 in Pathophysiology |
title_fullStr |
Emerging Roles of BRD7 in Pathophysiology |
title_full_unstemmed |
Emerging Roles of BRD7 in Pathophysiology |
title_sort |
emerging roles of brd7 in pathophysiology |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-09-01 |
description |
Bromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. Decreased BRD7 activity underlies the pathophysiological properties of various diseases in different organs. BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with a focus on glucose homeostasis, obesity, and cancer. |
topic |
BRD7 glucose metabolism type 2 diabetes XBP1s PI3K p85 |
url |
https://www.mdpi.com/1422-0067/21/19/7127 |
work_keys_str_mv |
AT sangwonpark emergingrolesofbrd7inpathophysiology AT junsikmlee emergingrolesofbrd7inpathophysiology |
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1724471676524036096 |