Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia
Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence als...
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doaj-690f1ae035be40399c86d69648edfe972021-01-06T06:05:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-01-011410.3389/fnhum.2020.597694597694Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive AphasiaHeather R. Dial0G. Nike Gnanateja1Rachel S. Tessmer2Maria Luisa Gorno-Tempini3Bharath Chandrasekaran4Bharath Chandrasekaran5Maya L. Henry6Maya L. Henry7Aphasia Research and Treatment Lab, Department of Speech, Language, and Hearing Sciences, University of Texas at Austin, Austin, TX, United StatesSoundBrain Lab, Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, United StatesAphasia Research and Treatment Lab, Department of Speech, Language, and Hearing Sciences, University of Texas at Austin, Austin, TX, United StatesLanguage Neurobiology Laboratory, Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United StatesSoundBrain Lab, Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, United StatesCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United StatesAphasia Research and Treatment Lab, Department of Speech, Language, and Hearing Sciences, University of Texas at Austin, Austin, TX, United StatesDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, United StatesLogopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence also implicates impaired speech perception. Currently, neural encoding of the speech envelope, which forms the scaffolding for perception, is not clearly understood in lvPPA. We leveraged recent analytical advances in electrophysiology to examine speech envelope encoding in lvPPA. We assessed cortical tracking of the speech envelope and in-task comprehension of two spoken narratives in individuals with lvPPA (n = 10) and age-matched (n = 10) controls. Despite markedly reduced narrative comprehension relative to controls, individuals with lvPPA had increased cortical tracking of the speech envelope in theta oscillations, which track low-level features (e.g., syllables), but not delta oscillations, which track speech units that unfold across a longer time scale (e.g., words, phrases, prosody). This neural signature was highly correlated across narratives. Results indicate an increased reliance on acoustic cues during speech encoding. This may reflect inefficient encoding of bottom-up speech cues, likely as a consequence of dysfunctional temporoparietal cortex.https://www.frontiersin.org/articles/10.3389/fnhum.2020.597694/fulllogopenic variantlogopenic variant of primary progressive aphasia (lvPPA)cortical tracking of speechtemporal response function (TRF)speech perceptionspeech envelope |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heather R. Dial G. Nike Gnanateja Rachel S. Tessmer Maria Luisa Gorno-Tempini Bharath Chandrasekaran Bharath Chandrasekaran Maya L. Henry Maya L. Henry |
spellingShingle |
Heather R. Dial G. Nike Gnanateja Rachel S. Tessmer Maria Luisa Gorno-Tempini Bharath Chandrasekaran Bharath Chandrasekaran Maya L. Henry Maya L. Henry Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia Frontiers in Human Neuroscience logopenic variant logopenic variant of primary progressive aphasia (lvPPA) cortical tracking of speech temporal response function (TRF) speech perception speech envelope |
author_facet |
Heather R. Dial G. Nike Gnanateja Rachel S. Tessmer Maria Luisa Gorno-Tempini Bharath Chandrasekaran Bharath Chandrasekaran Maya L. Henry Maya L. Henry |
author_sort |
Heather R. Dial |
title |
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia |
title_short |
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia |
title_full |
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia |
title_fullStr |
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia |
title_full_unstemmed |
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia |
title_sort |
cortical tracking of the speech envelope in logopenic variant primary progressive aphasia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2021-01-01 |
description |
Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence also implicates impaired speech perception. Currently, neural encoding of the speech envelope, which forms the scaffolding for perception, is not clearly understood in lvPPA. We leveraged recent analytical advances in electrophysiology to examine speech envelope encoding in lvPPA. We assessed cortical tracking of the speech envelope and in-task comprehension of two spoken narratives in individuals with lvPPA (n = 10) and age-matched (n = 10) controls. Despite markedly reduced narrative comprehension relative to controls, individuals with lvPPA had increased cortical tracking of the speech envelope in theta oscillations, which track low-level features (e.g., syllables), but not delta oscillations, which track speech units that unfold across a longer time scale (e.g., words, phrases, prosody). This neural signature was highly correlated across narratives. Results indicate an increased reliance on acoustic cues during speech encoding. This may reflect inefficient encoding of bottom-up speech cues, likely as a consequence of dysfunctional temporoparietal cortex. |
topic |
logopenic variant logopenic variant of primary progressive aphasia (lvPPA) cortical tracking of speech temporal response function (TRF) speech perception speech envelope |
url |
https://www.frontiersin.org/articles/10.3389/fnhum.2020.597694/full |
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