Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing a...
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doaj-6917a82f2e1d4c199c2071827138f8fa2020-11-25T02:34:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-11-011911355210.3390/ijms19113552ijms19113552Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy BalanceBaile Wang0Kenneth King-Yip Cheng1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, ChinaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, ChinaAs a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing appetite to increase food intake and diminishing adaptive thermogenesis in adipose tissues to reduce energy expenditure in response to food deprivation. Numerous metabolic hormones, such as leptin, adiponectin, ghrelin and insulin, exert their energy regulatory effects through hypothalamic AMPK via integration with the neural circuits. Although activation of AMPK in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. In this review, we discuss the role of hypothalamic AMPK in mediating hormonal regulation of feeding and adaptive thermogenesis, and summarize the diverse underlying mechanisms by which central AMPK maintains energy homeostasis.https://www.mdpi.com/1422-0067/19/11/3552hypothalamusadenosine monophosphate-activated protein kinaseadipose tissuefood intakeadaptive thermogenesisbeiging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Baile Wang Kenneth King-Yip Cheng |
spellingShingle |
Baile Wang Kenneth King-Yip Cheng Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance International Journal of Molecular Sciences hypothalamus adenosine monophosphate-activated protein kinase adipose tissue food intake adaptive thermogenesis beiging |
author_facet |
Baile Wang Kenneth King-Yip Cheng |
author_sort |
Baile Wang |
title |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
title_short |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
title_full |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
title_fullStr |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
title_full_unstemmed |
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
title_sort |
hypothalamic ampk as a mediator of hormonal regulation of energy balance |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-11-01 |
description |
As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing appetite to increase food intake and diminishing adaptive thermogenesis in adipose tissues to reduce energy expenditure in response to food deprivation. Numerous metabolic hormones, such as leptin, adiponectin, ghrelin and insulin, exert their energy regulatory effects through hypothalamic AMPK via integration with the neural circuits. Although activation of AMPK in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. In this review, we discuss the role of hypothalamic AMPK in mediating hormonal regulation of feeding and adaptive thermogenesis, and summarize the diverse underlying mechanisms by which central AMPK maintains energy homeostasis. |
topic |
hypothalamus adenosine monophosphate-activated protein kinase adipose tissue food intake adaptive thermogenesis beiging |
url |
https://www.mdpi.com/1422-0067/19/11/3552 |
work_keys_str_mv |
AT bailewang hypothalamicampkasamediatorofhormonalregulationofenergybalance AT kennethkingyipcheng hypothalamicampkasamediatorofhormonalregulationofenergybalance |
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1724808152609718272 |