Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children
Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outc...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
|
Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/2012/398628 |
id |
doaj-69187f48a37b494687bf400714483eb9 |
---|---|
record_format |
Article |
spelling |
doaj-69187f48a37b494687bf400714483eb92020-11-24T21:28:52ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512012-01-01201210.1155/2012/398628398628Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese ChildrenYa-Ling Yang0Wei-Pin Chang1Yu-Wen Hsu2Wei-Chiao Chen3Hong-Ren Yu4Chi-Di Liang5Yao-Ting Tsai6Ying-Hsien Huang7Kuender D. Yang8Ho-Chang Kuo9Wei-Chiao Chang10Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Healthcare Management, Yuanpei University, HsinChu 30015, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Allergy, Immunology and Rheumatology of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Medical Research, Show Chwan Memorial Hospital in Chang Bing, Changhua 505, TaiwanDivision of Allergy, Immunology and Rheumatology of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanBackground. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD. Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test. Results. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response. Conclusions. This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.http://dx.doi.org/10.1155/2012/398628 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ya-Ling Yang Wei-Pin Chang Yu-Wen Hsu Wei-Chiao Chen Hong-Ren Yu Chi-Di Liang Yao-Ting Tsai Ying-Hsien Huang Kuender D. Yang Ho-Chang Kuo Wei-Chiao Chang |
spellingShingle |
Ya-Ling Yang Wei-Pin Chang Yu-Wen Hsu Wei-Chiao Chen Hong-Ren Yu Chi-Di Liang Yao-Ting Tsai Ying-Hsien Huang Kuender D. Yang Ho-Chang Kuo Wei-Chiao Chang Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children Journal of Biomedicine and Biotechnology |
author_facet |
Ya-Ling Yang Wei-Pin Chang Yu-Wen Hsu Wei-Chiao Chen Hong-Ren Yu Chi-Di Liang Yao-Ting Tsai Ying-Hsien Huang Kuender D. Yang Ho-Chang Kuo Wei-Chiao Chang |
author_sort |
Ya-Ling Yang |
title |
Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children |
title_short |
Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children |
title_full |
Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children |
title_fullStr |
Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children |
title_full_unstemmed |
Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children |
title_sort |
lack of association between clec5a gene single-nucleotide polymorphisms and kawasaki disease in taiwanese children |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2012-01-01 |
description |
Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD.
Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test. Results. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response. Conclusions. This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population. |
url |
http://dx.doi.org/10.1155/2012/398628 |
work_keys_str_mv |
AT yalingyang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT weipinchang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT yuwenhsu lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT weichiaochen lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT hongrenyu lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT chidiliang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT yaotingtsai lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT yinghsienhuang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT kuenderdyang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT hochangkuo lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren AT weichiaochang lackofassociationbetweenclec5agenesinglenucleotidepolymorphismsandkawasakidiseaseintaiwanesechildren |
_version_ |
1725968819186302976 |